Evidence map›Paper›PMID 33602208›Full record

ArticleCardiovascular diabetology2021

Triglyceride-glucose index and the risk of stroke and its subtypes in the general population: an 11-year follow-up.

Anxin Wang, Guangyao Wang, Qian Liu, Yingting Zuo, Shuohua Chen, Boni Tao, Xue Tian, Penglian Wang, Xia Meng, Shouling Wu and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular diabetology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 6 pooled it
34.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 6 syntheses or guidelines pooled it, 287 citations in OpenAlex.

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  9. Blood-Based Biomarkers for Post-Stroke Cognitive Impairment.Current issues in molecular biology · 2026
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64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Anxin Wang *Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.119, South 4th Ring West Road, Fengtai District, Beijing, 100070, China.
Guangyao Wang *Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.119, South 4th Ring West Road, Fengtai District, Beijing, 100070, China.
Qian LiuGraduate School, North China University of Science and Technology, Tangshan, China.
Yingting ZuoDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China.
Shuohua ChenDepartment of Cardiology, Kailuan General Hospital, North China University of Science and Technology, No.57 Xinhua East Street, Lubei District, Tangshan, 063000, China.
Boni TaoSchool of Public Health, North China University of Science and Technology, Tangshan, China.
Xue TianDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China.
Penglian WangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.119, South 4th Ring West Road, Fengtai District, Beijing, 100070, China.
Xia MengDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.119, South 4th Ring West Road, Fengtai District, Beijing, 100070, China.
Shouling WuDepartment of Cardiology, Kailuan General Hospital, North China University of Science and Technology, No.57 Xinhua East Street, Lubei District, Tangshan, 063000, China. drwusl@163.com.
Yongjun WangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.119, South 4th Ring West Road, Fengtai District, Beijing, 100070, China. yongjunwang@ncrcnd.org.cn.
Yilong WangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.119, South 4th Ring West Road, Fengtai District, Beijing, 100070, China. yilong528@gmail.com.ORCID 0000-0003-2725-2788
Capital Medical University · CNNorth China University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTriglyceride-glucose (TyG) index was recently suggested to be a reliable surrogate marker of insulin resistance. We aim to investigate the associations between baseline and long-term TyG index with subsequent stroke and its subtypes in a community-based cohort.

methodsA total of 97,653 participants free of history of stroke in the Kailuan Study were included. TyG index was calculated as ln (fasting triglyceride [mg/dL] × fasting glucose [mg/dL]/2). Baseline TyG index was measured during 2006-2007. Updated cumulative average TyG index used all available TyG index from baseline to the outcome events of interest or the end of follow up. The outcome was the first occurrence of stroke, including ischemic stroke, intracerebral hemorrhage and subarachnoid hemorrhage. The associations of TyG index with outcomes were explored with Cox regression.

resultsDuring a median of 11.02 years of follow-up, 5122 participants developed stroke of whom 4277 were ischemic stroke, 880 intracerebral hemorrhage, and 144 subarachnoid hemorrhage. After adjusting for confounding variables, compared with participants in the lowest quartile of baseline TyG index, those in the third and fourth quartile were associated with an increased risk of stroke (adjusted hazard ratio [HR] 1.22, 95% confidence interval [CI] 1.12-1.33, and adjusted HR 1.32, 95% CI 1.21-1.44, respectively, P for trend < 0.001). We also found a linear association between baseline TyG index with stroke. Similar results were found for ischemic stroke. However, no significant associations were observed between baseline TyG index and risk of intracranial hemorrhage. Parallel results were observed for the associations of updated cumulative average TyG index with outcomes.

conclusionsElevated levels of both baseline and long-term updated cumulative average TyG index can independently predict stroke and ischemic stroke but not intracerebral hemorrhage in the general population during an 11-year follow-up.

Indexed as

Insulin ResistanceAdultBiomarkersBlood GlucoseCerebral HemorrhageChinaFemaleFollow-Up StudiesHumansIschemic StrokeMaleMiddle AgedPredictive Value of TestsPrognosisProspective StudiesRisk AssessmentBiomarkersBlood GlucoseTriglyceridesInsulin resistanceStrokeTriglyceride-glucose index

Identifiers

PMID33602208
PMCPMC7893902
OpenAlexW3130141704

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.