Evidence map›Paper›PMID 33602870›Full record

ArticleGenes & development2021

BAF subunit switching regulates chromatin accessibility to control cell cycle exit in the developing mammalian cortex.

Simon M G Braun, Ralitsa Petrova, Jiong Tang, Andrey Krokhotin, Erik L Miller, Yitai Tang, Georgia Panagiotakos, Gerald R Crabtree

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & development, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 54 citations in OpenAlex.

  1. Review
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  13. Actin-Like Protein 6A as an Oncogene and Therapeutic Target in Cancer.International journal of medical sciences · 2025
    Review
  14. Article
  15. Epigenetics and the timing of neuronal differentiation.Current opinion in neurobiology · 2024
    Review
  16. Review
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  18. Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Simon M G Braun *Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA.
Ralitsa Petrova *Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94143, USA.
Jiong TangHoward Hughes Medical Institute, Stanford University, Stanford, California 94305, USA.
Andrey KrokhotinHoward Hughes Medical Institute, Stanford University, Stanford, California 94305, USA.
Erik L MillerHoward Hughes Medical Institute, Stanford University, Stanford, California 94305, USA.
Yitai TangDepartment of Pathology, Stanford University, California 94305, USA.
Georgia PanagiotakosDepartment of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94143, USA.ORCID 0000-0001-9444-2480
Gerald R CrabtreeHoward Hughes Medical Institute, Stanford University, Stanford, California 94305, USA.
Howard Hughes Medical Institute · USUniversity of California, San Francisco · USAgency for Science, Technology and Research · SGStanford University · USUniversity of Geneva · CH

Funding

ATP-Dependent Chromatin Remodeling in Human MalignancyR01CA163915 · NCI · STANFORD UNIVERSITY · PI Gerald R. Crabtree · 2012 to 2026
$5.4M
Signaling by Calcineurin and NFAT in Axonal OutgrowthR01NS046789 · NINDS · STANFORD UNIVERSITY · PI CRABTREE, GERALD R. · 2003 to 2012
$3.4M
ATP-Dependent Chromatin Regulation in Neurodevelopment and Human DiseaseR37NS046789 · NINDS · STANFORD UNIVERSITY · PI CRABTREE, GERALD R. · 2013 to 2019
$2.7M
HIJACKING CANCER DRIVERS TO ACTIVATE PROAPOPTOTIC GENES IN DLBCLR01CA276167 · NCI · STANFORD UNIVERSITY · PI Gerald R. Crabtree, NATHANAEL Schiander GRAY · 2023 to 2026
$2.2M
Howard Hughes Medical InstituteNCI NIH HHS R01 CA163915NCI NIH HHS R01 CA276167NINDS NIH HHS R01 NS046789NINDS NIH HHS R37 NS046789
6 · The paper itself

Abstract

mSWI/SNF or BAF chromatin regulatory complexes are dosage-sensitive regulators of human neural development frequently mutated in autism spectrum disorders and intellectual disability. Cell cycle exit and differentiation of neural stem/progenitor cells is accompanied by BAF subunit switching to generate neuron-specific nBAF complexes. We manipulated the timing of BAF subunit exchange in vivo and found that early loss of the npBAF subunit BAF53a stalls the cell cycle to disrupt neurogenesis. Loss of BAF53a results in decreased chromatin accessibility at specific neural transcription factor binding sites, including the pioneer factors SOX2 and ASCL1, due to Polycomb accumulation. This results in repression of cell cycle genes, thereby blocking cell cycle progression and differentiation. Cell cycle block upon

Indexed as

Gene Expression Regulation, DevelopmentalActinsAnimalsBinding SitesCell CycleCells, CulturedCerebellar CortexChromatinChromosomal Proteins, Non-HistoneDNA-Binding ProteinsEmbryo, MammalianGene DeletionGenes, cdcMiceNeurogenesisPolycomb-Group ProteinsActinsActl6a protein, mouseChromatinChromosomal Proteins, Non-HistoneDNA-Binding ProteinsPolycomb-Group ProteinsTranscription FactorsBAF complexcell cycle exitcell type-specific transcriptional networkschromatin accessibilitycortical developmentneurogenesis

Identifiers

PMID33602870
PMCPMC7919417
OpenAlexW3132973910

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.