Evidence map›Paper›PMID 33604492›Full record

ArticleCurrent opinion in toxicology2019

Public data sources to support systems toxicology applications.

Allan Peter Davis, Jolene Wiegers, Thomas C Wiegers, Carolyn J Mattingly

Open access · greenAbstract read
In one paragraph

Article in Current opinion in toxicology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Evolving Science and Practice of Risk Assessment.Risk analysis : an official publication of the Society for Risk Analysis · 2021
    Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Allan Peter DavisDepartment of Biological Sciences, North Carolina State University, Raleigh, North Carolina 27695, United States.
Jolene WiegersDepartment of Biological Sciences, North Carolina State University, Raleigh, North Carolina 27695, United States.
Thomas C WiegersDepartment of Biological Sciences, North Carolina State University, Raleigh, North Carolina 27695, United States.
Carolyn J MattinglyDepartment of Biological Sciences, North Carolina State University, Raleigh, North Carolina 27695, United States.
North Carolina State University · US

Funding

Translational Research Support CoreP30ES025128 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Sue Fenton · 2015 to 2026
$18.3M
The Comparative Toxicogenomics Database (CTD)R01ES014065 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI DAVIS, ALLAN PETER, MATTINGLY, CAROLYN J. · 2006 to 2021
$10.5M
Comparative Toxicogenomics Database (CTD)U24ES033155 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Allan Peter Davis, Carolyn J. Mattingly · 2021 to 2026
$9.3M
Advancing mechanism-based studies with cross-species chemical-phenotype dataR01ES023788 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI MATTINGLY, CAROLYN J. · 2015 to 2019
$1.6M
NIEHS NIH HHS P30 ES025128NIEHS NIH HHS R01 ES014065NIEHS NIH HHS R01 ES023788NIEHS NIH HHS U24 ES033155
6 · The paper itself

Abstract

Public databases provide a wealth of freely available information about chemicals, genes, proteins, biological networks, phenotypes, diseases, and exposure science that can be integrated to construct pathways for systems toxicology applications. Relating this disparate information from public repositories, however, can be challenging since databases use a variety of ways to represent, describe, and make available their content. The use of standard vocabularies to annotate key data concepts, however, allows the information to be more easily exchanged and combined for discovery of new findings. We explore some of the many public data sources currently available to support systems toxicology, and demonstrate the value of standardizing data to help construct chemical-induced outcome pathways.

Indexed as

ChemicalData standardDiseaseGenePublic databaseSystems toxicology

Identifiers

PMID33604492
PMCPMC7889036
OpenAlexW2922014097

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.