Other glucose-lowering × cardiovascular events

SynthesisPloS one2021

Cardiovascular outcomes associated with SGLT-2 inhibitors versus other glucose-lowering drugs in patients with type 2 diabetes: A real-world systematic review and meta-analysis.

Chun-Xing Li et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedas reported · 157,259 people · 2021

Not counted

Reduced cardiovascular events

−29%−33% to −25%

Bigger than 7 in 10 for cardiovascular events

As reported

OR 0.71, 95% CI 0.67–0.75

Not counted

Reduced cardiovascular events

−47%−51% to −43%

Bigger than 9 in 10 for cardiovascular events

As reported

OR 0.53, 95% CI 0.49–0.57

Not counted

Reduced cardiovascular events

−44%−52% to −33%

Bigger than 9 in 10 for cardiovascular events

As reported

OR 0.56, 95% CI 0.48–0.67

Not counted

Reduced cardiovascular events

−44%−54% to −32%

Bigger than 9 in 10 for cardiovascular events

As reported

OR 0.56, 95% CI 0.46–0.68

+5 more in the walkthrough ↓

Nine numbers in the abstract

the abstract, start to end

SGLT-2i reduced MACE (OR, 0.71; 95% CI 0.67,0.75, P<0.001) and ACM (OR, 0.53; 95% CI 0.49,0.57, P<0.001)

lowered the risk of HHF (OR, 0.56; 95% CI 0.46,0.68, P<0.001), MI (OR, 0.77; 95% CI 0.73,0.81, P<0.001), stroke (OR, 0.75; 95% CI 0.72,0.78, P<0.001), CVM (OR, 0.58; 95% CI 0.49,0.69, P<0.001) and HF (OR, 0.56; 95% CI 0.48,0.67, P<0.001),

the risk of severe hypoglycemia (OR, 0.78; 95% CI 0.69,0.90, P<0.001) and lower limb amputation (OR, 0.83; 95% CI 0.71,0.98, P<0.001),

← favours treatmentfavours comparator →
could be chance
Cardiovascular events
OR 0.710.67–0.75
Cardiovascular events
OR 0.530.49–0.57
Cardiovascular events
OR 0.560.48–0.67
Cardiovascular events
OR 0.560.46–0.68
Cardiovascular events
OR 0.770.73–0.81
Cardiovascular events
OR 0.750.72–0.78
Cardiovascular events
OR 0.580.49–0.69
Hypoglycaemia
OR 0.780.69–0.90
Cardiovascular events
OR 0.830.71–0.98
SGLT2 inhibitorsOther glucose-loweringCardiovascular eventsHypoglycaemia
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