Evidence map›Paper›PMID 33623673›Full record

ReviewClinical kidney journal2021

Oncogenic mechanisms in renal insufficiency.

Simona Ruxandra Volovat, Constantin Volovat, Ingrith Miron, Mehmet Kanbay, David Goldsmith, Cristian Lungulescu, Silvia Corina Badarau, Adrian Covic

Open access · goldAbstract readReview
In one paragraph

Review in Clinical kidney journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Simona Ruxandra VolovatDepartment of Medical Oncology, University of Medicine and Pharmacy 'Grigore T Popa', Iasi, Romania.
Constantin VolovatDepartment of Medical Oncology, University of Medicine and Pharmacy 'Grigore T Popa', Iasi, Romania.
Ingrith MironDepartment of Medical Oncology, University of Medicine and Pharmacy 'Grigore T Popa', Iasi, Romania.
Mehmet KanbayDepartment of Nephrology, Division of Nephrology, Department of Medicine, Koc University School of Medicine, Istanbul, Turkey.ORCID 0000-0002-1297-0675
David GoldsmithDepartment of Nephrology, St George's University Hospital, London, UK.
Cristian LungulescuDepartment of Medical Oncology, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
Silvia Corina BadarauDepartment of Medical Oncology, University of Medicine and Pharmacy 'Grigore T Popa', Iasi, Romania.
Adrian CovicDepartment of Medical Oncology, University of Medicine and Pharmacy 'Grigore T Popa', Iasi, Romania.
Grigore T. Popa University of Medicine and Pharmacy · ROKoç University · TRSt George's Hospital · GBUniversity of Medicine and Pharmacy of Craiova · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence of both cancer and end-stage renal disease is increasing. In addition, medical advances have meant increased survival rates for both diseases. Many chemotherapeutics are renally excreted, and conversely, renal insufficiency promotes a pro-neoplastic state, including genitourinary and other cancers. Dialysis prolongs life while increasing cancer risk. Proposed oncogenic mechanisms include immune dysfunction, chronic inflammation, changes in gut microbiota and stimulation of the renin-angiotensin system. This review summarizes current concepts in the relationship between cancer and renal insufficiency.

Indexed as

cancercarcinogenesisend-stage renal diseasemalignancyrenal transplant

Identifiers

PMID33623673
PMCPMC7886561
OpenAlexW3093936877

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.