ArticleObesity (Silver Spring, Md.)2021
Sex Differences in Insulin Sensitivity are Related to Muscle Tissue Acylcarnitine But Not Subcellular Lipid Distribution.
Article in Obesity (Silver Spring, Md.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Molecular basis of insulin resistance and its impact on the brain: the role of physical exercise.Molecular biology reports · 2026Review
- Sex-specific aspects in the development of tissue metabolic damage in a non-obese prediabetic model.Frontiers in endocrinology · 2026Article
- From glucose to histone modification: sex-specific metabolic responses to ketogenic therapy in VM/Dk mice.Frontiers in nutrition · 2025Article
- Circulating Citrate Is Reversibly Elevated in Patients with End-Stage Liver Disease: Association with All-Cause Mortality.International journal of molecular sciences · 2024Observational
- Relationship between body adiposity parameters and insulin resistance: a preliminary study of surrogate markers in Japan.Hormones (Athens, Greece) · 2024Article
- Intramuscular diacylglycerol accumulates with acute hyperinsulinemia in insulin-resistant phenotypes.American journal of physiology. Endocrinology and metabolism · 2024Article
- Plasma Citrate Levels Are Associated with an Increased Risk of Cardiovascular Mortality in Patients with Type 2 Diabetes (Zodiac-64).Journal of clinical medicine · 2023Article
- Sexual dimorphism in COVID-19: potential clinical and public health implications.The lancet. Diabetes & endocrinology · 2022Review
- Western diet augments metabolic and arterial dysfunction in a sex-specific manner in outbred, genetically diverse mice.Frontiers in nutrition · 2022Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveSex differences in insulin sensitivity are present throughout the life-span, with men having a higher prevalence of insulin resistance and diabetes compared with women. Differences in lean mass, fat mass, and fat distribution-particularly ectopic fat-have all been postulated to contribute to the sexual dimorphism in diabetes risk. Emerging data suggest ectopic lipid composition and subcellular localization are most relevant; however, it is not known whether they explain sex differences in obesity-induced insulin resistance.
methodsTo address this gap, this study evaluated insulin sensitivity and subcellular localization of intramuscular triacylglycerol, diacylglycerol, and sphingolipids as well as muscle acylcarnitines and serum lipidomics in people with obesity.
resultsInsulin sensitivity was significantly lower in men (P < 0.05); however, no sex differences were found in localization of intramuscular triacylglycerol, diacylglycerol, or sphingolipids in skeletal muscle. In contrast, men had higher total muscle acylcarnitine (P < 0.05) and long-chain muscle acylcarnitine (P < 0.05), which were related to lower insulin sensitivity (r = -0.42, P < 0.05). Men also displayed higher serum ceramide (P = 0.05) and lysophosphatidylcholine (P < 0.01).
conclusionsThese data reveal novel sex-specific associations between lipid species involved in the coupling of mitochondrial fatty acid transport, β-oxidation, and tricarboxylic acid cycle flux that may provide therapeutic targets to improve insulin sensitivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.