ArticleScience advances2021
Goal-dependent tuning of muscle spindle receptors during movement preparation.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- [Effectiveness Analysis of Cervical Rotation-Traction Manipulation on Cervical and Dorsal Muscle Tone in Patients With Cervical Spondylotic Radiculopathy].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Article
- Eccentric Exercise and Muscle Damage: An Introductory Guide.Journal of functional morphology and kinesiology · 2026Review
- Article
- Muscle spindles provide flexible sensory feedback for movement sequences.Cell reports · 2025Article
- Adaptation of Transcortical Responses in Upper Extremity Movements During an Elbow Visuomotor Tracking Task in Humans.Journal of functional morphology and kinesiology · 2025Article
- Preparation duration shapes the goal-directed tuning of stretch reflex responses.Experimental brain research · 2025Article
- Upper limb muscle reflexes in real and virtual environments: Insights into sensorimotor adaptations.PloS one · 2025Article
- Article
- A computational study of how an α- to γ-motoneurone collateral can mitigate velocity-dependent stretch reflexes during voluntary movement.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Quantity and Distribution of Muscle Spindles in Animal and Human Muscles.International journal of molecular sciences · 2024Review
- An alpha- to gamma-motoneurone collateral can mitigate velocity-dependent stretch reflexes during voluntary movement: A computational study.bioRxiv : the preprint server for biology · 2024Article
- Article
- Short-latency stretch reflexes depend on the balance of activity in agonist and antagonist muscles during ballistic elbow movements.Journal of neurophysiology · 2023Article
- A Method for Quantification of Stretch Reflex Excitability During Ballistic Reaching.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2023Article
- Evaluation of stretch reflex synergies in the upper limb using principal component analysis (PCA).PloS one · 2023Article
- Article
- Evidence for constancy in the modularity of trunk muscle activity preceding reaching: implications for the role of preparatory postural activity.Journal of neurophysiology · 2021Article
- Hybrid dedicated and distributed coding in PMd/M1 provides separation and interaction of bilateral arm signals.PLoS computational biology · 2021Article
- Passive Proprioceptive Training Alters the Sensitivity of Muscle Spindles to Imposed Movements.eNeuroArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Voluntary movements are believed to undergo preparation before they are executed. Preparatory activity can benefit reaction time and the quality of planned movements, but the neural mechanisms at work during preparation are unclear. For example, there are no overt changes in muscle force during preparation. Here, using an instructed-delay manual task, we demonstrate a decrease in human muscle afferent activity (primary spindles) when preparing to reach targets in directions associated with stretch of the spindle-bearing muscle. This goal-dependent modulation of proprioceptors began early after target onset but was markedly stronger at the latter parts of the preparatory period. Moreover, whole-arm perturbations during reach preparation revealed a modulation of stretch reflex gains (shoulder and upper arm muscles) that reflected the observed changes in spindle activity. We suggest that one function of central preparatory activity is to tune muscle stiffness according to task goals via the independent control of muscle spindle sensors.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.