ArticleThe Journal of clinical endocrinology and metabolism2021
Longitudinal Investigation of Pubertal Milestones and Hormones as a Function of Body Fat in Girls.
Article in The Journal of clinical endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07437976 (A Natural History of Genetic and Environmental Predictors of Pubertal Timing Among Youth With Obesity), which is not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Natural History of Genetic and Environmental Predictors of Pubertal Timing Among Youth With Obesity
Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Highly specific ID-UHPLC-MS/MS method for analyzing polar and non-polar steroid hormones.Analytical and bioanalytical chemistry · 2026Article
- Factors associated with weight loss behaviors among Korean female adolescents: a bio-psycho-social model approach.Child health nursing research · 2026Article
- Evidence for Functional Ovarian Hyperandrogenism in Early Pubertal, but Not Late Pubertal, Girls With Excess Weight.Journal of the Endocrine Society · 2025Article
- The influence of adiposity status and the trajectories of obesity indicators on earlier puberty onset in girls: a longitudinal cohort study in Shanghai, China.BMC public health · 2025Article
- Associations Between Weight-Related Measurements and Pubertal Markers in Norwegian Girls: The Bergen Growth Study 2.Journal of the Endocrine Society · 2025Article
- Normal weight obesity in adolescents: patterns and associated factors.Frontiers in nutrition · 2025Article
- Bile acids: potential links to overweight/obesity and androgen levels in pubertal girls.Frontiers in endocrinology · 2025Article
- Pubertal Girls With Overweight/Obesity Have Higher Androgen Levels-Can Metabolomics Tell us Why?The Journal of clinical endocrinology and metabolism · 2024Article
- Creatine Acts as a Mediator of the Causal Effect of Obesity on Puberty Onset in Girls: Evidence from Mediation Mendelian Randomization Study.Metabolites · 2024Article
- Epigenetic age acceleration is associated with speed of pubertal growth but not age of pubertal onset.Scientific reports · 2024Article
- Small for gestational age and age at menarche in a contemporary population-based U.S. sample.PloS one · 2024Article
- Association between body fat distribution and age at menarche: a two sample Mendelian randomization study.Frontiers in pediatrics · 2024Article
- Salivary Metabolomic Signatures and Body Mass Index in Italian Adolescents: A Pilot Study.Journal of the Endocrine Society · 2023Article
- The Launch of A Girl's First Period Study: Demystifying Reproductive Hormone Profiles in Adolescent Girls.Journal of pediatric and adolescent gynecology · 2022Article
- The effects of obesity on the menstrual cycle.Current problems in pediatric and adolescent health care · 2022Article
- Increased Incidence of Precocious Puberty in Girls During COVID-19 Pandemic: Early Indicator of the Upcoming Childhood Metabolic Syndrome Pandemic?Global pediatric health · 2022Article
- Longitudinal evaluation of breast tissue in healthy infants: Prevalence and relation to reproductive hormones and growth factors.Frontiers in endocrinology · 2022Article
- Identifying Environmental Endocrine Disruptors Associated With the Age at Menarche by Integrating a Transcriptome-Wide Association Study With Chemical-Gene-Interaction Analysis.Frontiers in endocrinology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
contextEpidemiologic studies have demonstrated that overweight/obese girls (OW/OB) undergo thelarche and menarche earlier than normal weight girls (NW). There have been no longitudinal studies to specifically investigate how body weight/fat affects both clinical and biochemical pubertal markers in girls.
objectiveTo investigate the effect of total body fat on reproductive hormones and on the maturation of estrogen-sensitive tissues during puberty in girls.
methodsNinety girls (36 OW/OB, 54 NW), aged 8.2 to 14.7 years, completed 2.8 ± 1.7 study visits over 4 years. Visits included dual-energy x-ray absorptiometry to calculate total body fat (TBF), Tanner staging, breast ultrasound for morphological staging (BMORPH; A-E), pelvic ultrasound, hormone tests, and assessment of menarchal status. The effect of TBF on pubertal markers was determined using a mixed, multistate, or Cox proportional hazards model, controlling for baseline BMORPH.
resultsNW were older than OW/OB (11.3 vs 10.2 years, P < .01) at baseline and had more advanced BMORPH (P < .01). Luteinizing hormone, estradiol, and ovarian and uterine volumes increased with time with no effect of TBF. There was a time × TBF interaction for follicle-stimulating hormone, inhibin B, estrone, total and free testosterone, and androstenedione: Levels were initially similar, but after 1 year, levels increased in girls with higher TBF, plateaued in girls with midrange TBF, and decreased in girls with lower TBF. Girls with higher TBF progressed through BMORPH stage D more slowly but achieved menarche earlier than girls with lower TBF.
conclusionIn late puberty, girls with higher TBF demonstrate differences in standard hormonal and clinical markers of puberty. Investigation of the underlying causes and clinical consequences of these differences in girls with higher TBF deserves further study.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.