Evidence map›Paper›PMID 33633271›Full record

ArticleScientific reports2021

The influence of human genetic variation on Epstein-Barr virus sequence diversity.

Sina Rüeger, Christian Hammer, Alexis Loetscher, Paul J McLaren, Dylan Lawless, Olivier Naret, Nina Khanna, Enos Bernasconi, Matthias Cavassini, Huldrych F Günthard and 8 more

Erratum issuedAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. The potential impacts of human genetics on virus emergence.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. HIV-1 and human genetic variation.Nature reviews. Genetics · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Sina Rüeger *School of Life Sciences, EPFL, Lausanne, Switzerland.
Christian Hammer *Genentech Inc, 1 DNA Way, South San Francisco, CA, USA.
Alexis Loetscher *Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Paul J McLarenJC Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, MB, Canada.
Dylan LawlessSchool of Life Sciences, EPFL, Lausanne, Switzerland.
Olivier NaretSchool of Life Sciences, EPFL, Lausanne, Switzerland.
Nina KhannaDepartment of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
Enos BernasconiDivision of Infectious Diseases, Regional Hospital Lugano, Lugano, Switzerland.
Matthias CavassiniDivision of Infectious Diseases, University Hospital Lausanne, University of Lausanne, Lausanne, Switzerland.
Huldrych F GünthardDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Christian R KahlertDivision of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St.Gallen, St.Gallen, Switzerland.
Andri RauchDepartment of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland.
Daniel P DepledgeDivision of Infection and Immunity, University College London, London, UK.
Sofia MorfopoulouDivision of Infection and Immunity, University College London, London, UK.
Judith BreuerDivision of Infection and Immunity, University College London, London, UK.
Evgeny ZdobnovSwiss Institute of Bioinformatics, Lausanne, Switzerland.
Jacques FellaySchool of Life Sciences, EPFL, Lausanne, Switzerland. jacques.fellay@epfl.ch.
Swiss HIV Cohort Study

Funding

Wellcome Trust 206478Wellcome Trust 206478/Z/17/Z
6 · The paper itself

Abstract

Epstein-Barr virus (EBV) is one of the most common viruses latently infecting humans. Little is known about the impact of human genetic variation on the large inter-individual differences observed in response to EBV infection. To search for a potential imprint of host genomic variation on the EBV sequence, we jointly analyzed paired viral and human genomic data from 268 HIV-coinfected individuals with CD4 + T cell count < 200/mm

Indexed as

Genetic VariationGenome, ViralCohort StudiesEpstein-Barr Virus InfectionsHerpesvirus 4, HumanHigh-Throughput Nucleotide SequencingHumans

Identifiers

PMID33633271
PMCPMC7907281

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.