Evidence map›Paper›PMID 33634203›Full record

ArticleOpen forum infectious diseases2021

Concomitant Treatment of Chronic Hepatitis C With Direct-Acting Antivirals and Multidrug-Resistant Tuberculosis Is Effective and Safe.

Nara Melikyan, Helena Huerga, Hakob Atshemyan, Ohanna Kirakosyan, Narina Sargsyants, Tsovinar Aydinyan, Nora Saribekyan, Naira Khachatryan, Izabella Oganezova, Joana Falcao and 2 more

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Observational
  2. Observational
  3. Article
  4. Article
  5. Observational
  6. Co-administration of treatment for drug-resistant TB and hepatitis C.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2023
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nara MelikyanEpicentre, Paris, France.
Helena HuergaEpicentre, Paris, France.
Hakob AtshemyanMédecins Sans Frontières, Yerevan, Armenia.
Ohanna KirakosyanMédecins Sans Frontières, Yerevan, Armenia.
Narina SargsyantsMédecins Sans Frontières, Yerevan, Armenia.
Tsovinar AydinyanMinistry of Health, Yerevan, Armenia.
Nora SaribekyanMinistry of Health, Yerevan, Armenia.
Naira KhachatryanMédecins Sans Frontières, Yerevan, Armenia.
Izabella OganezovaMédecins Sans Frontières, Yerevan, Armenia.
Joana FalcaoEpicentre, Paris, France.
Suna BalkanMédecins Sans Frontières, Paris, France.
Cathy HewisonMédecins Sans Frontières, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We assessed effectiveness and safety of concomitant chronic hepatitis C virus (HCV) treatment with direct-acting antivirals (DAAs) and multidrug-resistant tuberculosis (MDR-TB). Of 322 MDR-TB patients (19.4% HCV), 30 were treated concomitantly (23.3% human immunodeficiency virus-positive). Overall, 76.7% achieved HCV treatment success (95.8% among tested). One patient (3.3%) experienced a serious adverse event.

Indexed as

chronic hepatitis Cdirect-acting antiviral drugsmultidrug-resistant tuberculosissofosbuvirvirus

Identifiers

PMID33634203
PMCPMC7896641

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.