Evidence map›Paper›PMID 33634382›Full record

Trial reportJournal of general internal medicine2021

Dissociation Between Long-term Weight Loss Intervention and Blood Pressure: an 18-month Randomized Controlled Trial.

Yftach Gepner, Nir Goldstein, Ilan Shelef, Dan Schwarzfuchs, Hila Zelicha, Anat Yaskolka Meir, Gal Tsaban, Ehud Grossman

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of general internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01530724 (Effect of Weight-loss Diet Strategies and Exercise on Dynamics of Body Fat Depots and Metabolic Rate), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01530724 phase3completednot on this map

Effect of Weight-loss Diet Strategies and Exercise on Dynamics of Body Fat Depots and Metabolic Rate

TypeinterventionalSponsorBen-Gurion University of the NegevRan2012 to 2014Enrolled224ConditionsObesityArmsWeight-loss diet strategy (+) exercise (PA), weight loss (-) exercise (PA)
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Yftach GepnerDepartment of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, and Sylvan Adams Sports Institute, Tel-Aviv University, Tel-Aviv, Israel. gepner@tauex.tau.ac.il.
Nir GoldsteinDepartment of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, and Sylvan Adams Sports Institute, Tel-Aviv University, Tel-Aviv, Israel.
Ilan ShelefSoroka University Medical Center, Beer-Sheva, Israel.
Dan SchwarzfuchsSoroka University Medical Center, Beer-Sheva, Israel.
Hila ZelichaFaculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Anat Yaskolka MeirFaculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Gal TsabanFaculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Ehud GrossmanDepartment of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, and Sylvan Adams Sports Institute, Tel-Aviv University, Tel-Aviv, Israel.
Ben-Gurion University of the Negev · ILSoroka Medical Center · ILTel Aviv University · ILSheba Medical Center · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObesity is associated with elevated blood pressure (BP). In patients with obesity and hypertension, weight loss lowers BP, but the long-term effect of weight loss on BP is less clear.

objectiveWe aimed to assess the effect of long-term weight loss intervention on BP in normotensive and hypertensive subjects.

designRandomized controlled trial.

participantsTwo hundred seventy-eight subjects (mean age 47.9 ± 9.3 years, 89% male, 56% hypertensive) with abdominal obesity or elevated serum triglycerides and low high-density lipoprotein cholesterol were recruited.

interventionEighteen-month weight loss intervention. MAIN MEASURES: Body weight and BP were measured at baseline, after 6 and 18 months.

resultsAfter 6 months of intervention, in the weight loss phase, body mass index (BMI) decreased by an average of -2.2±1.5 kg/m

conclusionWeight-loss intervention reduced BP in hypertensive patients, but this was not maintained in the long run. CLINICAL

trial registrationClinicalTrials.gov Identifier: NCT01530724.

Indexed as

HypertensionWeight LossAdultBlood PressureBody Mass IndexFemaleHumansMaleMiddle AgedObesityblood pressurebody mass indexhypertensionrandomized controlled trialweight loss

Identifiers

PMID33634382
PMCPMC8342649
OpenAlexW3132082903

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.