Evidence map›Paper›PMID 33636374›Full record

ArticleThe journal of pain2021

Nociceptor Overexpression of Na

Pedro Alvarez, Oliver Bogen, Paul G Green, Jon D Levine

Open access · greenAbstract read
In one paragraph

Article in The journal of pain, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. NaThe Journal of comparative neurology · 2026
    Article
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  4. Review
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Pedro AlvarezDepartment of Oral and Maxillofacial Surgery, University of California, San Francisco, San Francisco, California.
Oliver BogenDepartment of Oral and Maxillofacial Surgery, University of California, San Francisco, San Francisco, California; UCSF Pain and Addiction Research Center, University of California, San Francisco, San Francisco, California.
Paul G GreenDepartment of Oral and Maxillofacial Surgery, University of California, San Francisco, San Francisco, California; UCSF Pain and Addiction Research Center, University of California, San Francisco, San Francisco, California; Department of Preventative and Restorative Dental Sciences, University of California, San Francisco, San Francisco, California.
Jon D LevineDepartment of Oral and Maxillofacial Surgery, University of California, San Francisco, San Francisco, California; UCSF Pain and Addiction Research Center, University of California, San Francisco, San Francisco, California; Department of Medicine, University of California San Francisco, San Francisco, California. Electronic address: jon.levine@ucsf.edu.
University of California, San Francisco · US

Funding

Acute-to-Chronic Transition in Ergonomic Muscle Pain: Nociceptor MechanismsR01AR063312 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEVINE, JON DAVID · 2013 to 2022
$6.5M
NIAMS NIH HHS R01 AR063312
6 · The paper itself

Abstract

Adult rats previously submitted to neonatal limited bedding (NLB), a model of early-life stress, display muscle mechanical hyperalgesia and nociceptor hyperexcitability, the underlying mechanism for which is unknown. Since voltage-gated sodium channel subtype 7 (Na

Indexed as

Chronic PainHyperalgesiaMyalgiaNAV1.7 Voltage-Gated Sodium ChannelNociceptorsStress, PsychologicalAnimalsAnimals, NewbornDisease Models, AnimalFemaleMaleMAP Kinase Signaling SystemNociceptionPain ThresholdRatsRats, Sprague-DawleyNAV1.7 Voltage-Gated Sodium ChannelERK1/2Maternal neglectmuscle hyperalgesianeonatal limited beddingnociceptor hyperexcitability

Identifiers

PMID33636374
PMCPMC8406703
OpenAlexW3132028412

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.