Evidence map›Paper›PMID 33639259›Full record

ArticleOsteoarthritis and cartilage2021

Assessment of quantitative [

L Watkins, J MacKay, B Haddock, V Mazzoli, S Uhlrich, G Gold, F Kogan

Open access · greenAbstract read
In one paragraph

Article in Osteoarthritis and cartilage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Validation of quantitative [Annals of nuclear medicine · 2025
    Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Advances in cartilage imaging techniques.Nature reviews. Rheumatology · 2026
    Review
  8. Advances in molecular imaging for osteoarthritis.Connective tissue research · 2025
    Review
  9. Review
  10. Cartilage-SpecificBiomedicines · 2025
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Diagnostics (Basel, Switzerland) · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

L WatkinsDepartment of Bioengineering, Stanford University, Stanford CA, USA; Department of Radiology, Stanford University, Stanford CA, USA. Electronic address: lewatkin@stanford.edu.
J MacKayNorwich Medical School, University of East Anglia, Norwich, United Kingdom; Department of Radiology, University of Cambridge, Cambridge, United Kingdom.
B HaddockRigshospitalet, Copenhagen, Denmark.
V MazzoliDepartment of Radiology, Stanford University, Stanford CA, USA.
S UhlrichDepartment of Mechanical Engineering, Stanford University, Stanford CA, USA.
G GoldDepartment of Bioengineering, Stanford University, Stanford CA, USA; Department of Radiology, Stanford University, Stanford CA, USA.
F KoganDepartment of Radiology, Stanford University, Stanford CA, USA.
Stanford University · USRigshospitalet · DKStanford Medicine · USUniversity of East Anglia · GB

Funding

Rapid MRI for Evaluation of OsteoarthritisR01EB002524 · NIBIB · STANFORD UNIVERSITY · PI Akshay Chaudhari, Garry E Gold · 2003 to 2026
$10.1M
Rapid Low-Cost Quantitative 3D MRI and Gait Assessment of the KneeR01AR077604 · NIAMS · STANFORD UNIVERSITY · PI HARGREAVES, BRIAN ANDREW · 2020 to 2024
$3.2M
Development of Sodium Fluoride PET-MRI for Quantitative Assessment of Knee OsteoarthritisR01AR074492 · NIAMS · STANFORD UNIVERSITY · PI GOLD, GARRY E · 2019 to 2023
$2.4M
Advanced MR Imaging of Early OsteoarthritisK24AR062068 · NIAMS · STANFORD UNIVERSITY · PI GOLD, GARRY E · 2012 to 2022
$1.7M
Quantitative Assessment of Early Metabolic and Biochemical Changes in OsteoarthritisR00EB022634 · NIBIB · STANFORD UNIVERSITY · PI KOGAN, FELIKS · 2019 to 2021
$730k
NIAMS NIH HHS K24 AR062068NIAMS NIH HHS R01 AR074492NIAMS NIH HHS R01 AR077604NIBIB NIH HHS R00 EB022634NIBIB NIH HHS R01 EB002524
6 · The paper itself

Abstract

objectiveMolecular information derived from dynamic [

methodsEleven healthy volunteers and twenty OA subjects were included. Both knees of all subjects were scanned simultaneously using a 3T hybrid PET/MRI system. MRI MOAKS assessment was performed to score the presence and size of osteophytes, bone marrow lesions, and cartilage lesions. Subchondral bone kinetic parameters of bone perfusion (K

resultsMean and maximum SUV and kinetic parameters K

conclusionsResults suggest that bone metabolism is altered in OA subjects, including bone regions with and without structural findings, compared to healthy subjects. Kinetic parameters of [

Indexed as

Calcification, PhysiologicMagnetic Resonance ImagingPositron-Emission TomographyAgedContrast MediaFemaleFluorine RadioisotopesHumansMaleMiddle AgedOsteoarthritis, KneePatellaSodium FluorideTibiaContrast MediaFluorine RadioisotopesSodium Fluoride[(18)F]Sodium fluorideKneeMRIOsteoarthritisPET

Identifiers

PMID33639259
PMCPMC8159876
OpenAlexW3132708206

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.