ReviewAnnual review of biophysics2021
Directed Evolution of Microbial Communities.
Review in Annual review of biophysics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed.
- SynComs should be rigorously defined, not renamed.Nature communications · 2026Article
- Predicting the plastic biodegradation potential within microbial lineages and across global ecosystems.Microbial genomics · 2026Article
- Advances in biocontainment strategies of engineered microbes for use in humans.Current opinion in microbiology · 2026Review
- Inorganic nitrogen metabolic reprogramming of the gut microbiome drives fecal microbiota transplantation in ulcerative colitis.Nature communications · 2026Article
- Microbial biotechnology meets ecological theory: a unified framework to design industrial microbial consortia.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Review
- Review
- Novel artificial selection method improves function of simulated microbial communities.PLoS computational biology · 2026Article
- Selection and transmission of the gut microbiome alone can shift mammalian behavior.Nature communications · 2025Article
- Evolution of One Species Increases Resistance to Invasion in a Simple Synthetic Community.Microbial ecology · 2025Article
- Applying ecological principles to microbiome engineering.Nature microbiology · 2025Review
- Macroecological patterns in experimental microbial communities.PLoS computational biology · 2025Article
- Ecology and Evolutionary Biology as Frameworks to Study Wine Fermentations.Microbial biotechnology · 2025Review
- Directed Evolution of Microbial Communities in Fermented Foods: Strategies, Mechanisms, and Challenges.Foods (Basel, Switzerland) · 2025Review
- Functional team selection as a framework for local adaptation in plants and their belowground microbiomes.The ISME journal · 2025Review
- Ecological design of high-performance synthetic microbial communities: from theoretical foundations to functional optimization.ISME communications · 2025Review
- Development of a microbiome for phenolic metabolism based on a domestication approach from lab to industrial application.Communications biology · 2024Article
- Artificial selection improves pollutant degradation by bacterial communities.Nature communications · 2024Article
- Evolution and stability of complex microbial communities driven by trade-offs.Molecular systems biology · 2024Review
- Metabolic complexity drives divergence in microbial communities.Nature ecology & evolution · 2024Article
- Global WWTP Microbiome-based Integrative Information Platform: From experience to intelligence.Environmental science and ecotechnology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Directed evolution is a form of artificial selection that has been used for decades to find biomolecules and organisms with new or enhanced functional traits. Directed evolution can be conceptualized as a guided exploration of the genotype-phenotype map, where genetic variants with desirable phenotypes are first selected and then mutagenized to search the genotype space for an even better mutant. In recent years, the idea of applying artificial selection to microbial communities has gained momentum. In this article, we review the main limitations of artificial selection when applied to large and diverse collectives of asexually dividing microbes and discuss how the tools of directed evolution may be deployed to engineer communities from the top down. We conceptualize directed evolution of microbial communities as a guided exploration of an ecological structure-function landscape and propose practical guidelines for navigating these ecological landscapes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.