ArticleCurrent biology : CB2021
A novel family of secreted insect proteins linked to plant gall development.
Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 75 citations in OpenAlex.
- Rapidly evolving aphid gall effector proteins exhibit saposin-like folds.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Rapidly evolving aphid gall effector proteins exhibit saposin-like folds.bioRxiv : the preprint server for biology · 2026Article
- Evolutionarily entrenched odorant receptors for (iScience · 2026Article
- Schistosome esophageal gland factor MEG-8.2 drives host cell lysis and interacts with host immune proteins.PLoS pathogens · 2026Article
- Dasineura asteriae Reprograms the Flower Gene Expressions of Vegetative Organs to Create Flower-Like Gall in Aster scaber.Plant, cell & environment · 2025Article
- Molecular, genetic and biochemical strategies: rice's arsenal against gall midge.Molecular biology reports · 2025Review
- CAP peptides artificially induce insect-gall-like growth in different plant species.Plant & cell physiology · 2025Article
- Analysis of salivary proteins in gall-inducing psylla and their potential influence on host plants.BMC genomics · 2025Article
- Chromosome-level genome assembly of the aphid Megoura crassicauda.Scientific data · 2025Article
- Association Between Gall Structural and Metabolic Complexity: Evidence fromPlants (Basel, Switzerland) · 2025Article
- Transcriptome and phytohormone analysis reveal mechanism of gall formation byFrontiers in plant science · 2025Article
- Exploring the complex information processes underlying plant behavior.Plant signaling & behavior · 2024Review
- Two chromosome-level genome assemblies of galling aphids Slavum lentiscoides and Chaetogeoica ovagalla.Scientific data · 2024Article
- It's gall relative: metabolic profiling of two morphologically distinct oak leaf galls induced by cynipid wasps.Plant physiology · 2024Article
- Cynipid wasps systematically reprogram host metabolism and restructure cell walls in developing galls.Plant physiology · 2024Article
- From Galls to Cecidological Herbaria: The Role of Gall Collections in Modern Life Sciences.Life (Basel, Switzerland) · 2024Review
- Insights into the Superrosids phylogeny and flavonoid synthesis from the telomere-to-telomere gap-free genome assembly ofHorticulture research · 2024Article
- New Gall-Forming Insect Model,Insects · 2024Article
- A chromosome-level genome assembly of the Rhus gall aphid Schlechtendalia chinensis provides insight into the endogenization of Parvovirus-like DNA sequences.BMC genomics · 2024Article
- Advances in genome sequencing reveal changes in gene content that contribute to arthropod macroevolution.Development genes and evolution · 2023Review
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
In an elaborate form of inter-species exploitation, many insects hijack plant development to induce novel plant organs called galls that provide the insect with a source of nutrition and a temporary home. Galls result from dramatic reprogramming of plant cell biology driven by insect molecules, but the roles of specific insect molecules in gall development have not yet been determined. Here, we study the aphid Hormaphis cornu, which makes distinctive "cone" galls on leaves of witch hazel Hamamelis virginiana. We found that derived genetic variants in the aphid gene determinant of gall color (dgc) are associated with strong downregulation of dgc transcription in aphid salivary glands, upregulation in galls of seven genes involved in anthocyanin synthesis, and deposition of two red anthocyanins in galls. We hypothesize that aphids inject DGC protein into galls and that this results in differential expression of a small number of plant genes. dgc is a member of a large, diverse family of novel predicted secreted proteins characterized by a pair of widely spaced cysteine-tyrosine-cysteine (CYC) residues, which we named BICYCLE proteins. bicycle genes are most strongly expressed in the salivary glands specifically of galling aphid generations, suggesting that they may regulate many aspects of gall development. bicycle genes have experienced unusually frequent diversifying selection, consistent with their potential role controlling gall development in a molecular arms race between aphids and their host plants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.