Evidence map›Paper›PMID 33660953›Full record

ReviewStem cells translational medicine2021

Cell augmentation strategies for cardiac stem cell therapies.

Raquel Cruz-Samperio, Millie Jordan, Adam Perriman

Open access · goldAbstract readReview
In one paragraph

Review in Stem cells translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Biomimetic Cell Membrane-Coated Scaffolds for Enhanced Tissue Regeneration.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Cell augmentation strategies for cardiac stem cell therapies.Stem cells translational medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Raquel Cruz-SamperioSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
Millie JordanSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
Adam PerrimanSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.ORCID 0000-0003-2205-9364
University of Bristol · GB

Funding

Medical Research Council MR/S016430/1
6 · The paper itself

Abstract

Myocardial infarction (MI) has been the primary cause of death in developed countries, resulting in a major psychological and financial burden for society. Current treatments for acute MI are directed toward rapid restoration of perfusion to limit damage to the myocardium, rather than promoting tissue regeneration and subsequent contractile function recovery. Regenerative cell therapies (CTs), in particular those using multipotent stem cells (SCs), are in the spotlight for treatment post-MI. Unfortunately, the efficacy of CTs is somewhat limited by their poor long-term viability, homing, and engraftment to the myocardium. In response, a range of novel SC-based technologies are in development to provide additional cellular modalities, bringing CTs a step closer to the clinic. In this review, the current landscape of emerging CTs and their augmentation strategies for the treatment post-MI are discussed. In doing so, we highlight recent advances in cell membrane reengineering via genetic modifications, recombinant protein immobilization, and the utilization of soft biomimetic scaffold interfaces.

Indexed as

Myocardial InfarctionMyocardiumStem Cell TransplantationHumansMultipotent Stem CellsRegenerationWound Healingcardiaccell migrationcellular therapyclinical translation

Identifiers

PMID33660953
PMCPMC8133336
OpenAlexW3135578458

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.