Evidence map›Paper›PMID 33665761›Full record

ArticleAAPS PharmSciTech2021

A New Approach for Dry Eye Management By Mucoadhesive In situ Gel of Vitamin B12: Formulation, In vitro and In vivo Assessment.

Soad A Mohamad, Eman Alaaeldin, Raafat M A Abdallah, Heba F Mansour

Erratum issuedAbstract read
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In one paragraph

Article in AAPS PharmSciTech, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Soad A MohamadDepartment of Pharmaceutics, Faculty of Pharmacy, Deraya University, Minia, Egypt.
Eman AlaaeldinDepartment of Pharmaceutics, Faculty of Pharmacy, Deraya University, Minia, Egypt.
Raafat M A AbdallahDepartment of Ophthalmology, Faculty of Medicine, Minia University, Minia, Egypt.
Heba F MansourDepartment of Pharmaceutics, Faculty of Pharmacy, Minia University, P.O. Box: 61111, Minia, Egypt. heba_mansour@mu.edu.eg.ORCID http://orcid.org/0000-0002-2948-1691
Deraya UniversityMinia University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The commitment of the existent study was to develop a mucoadhesive in situ gel systems of vitamin B12 for the management of dry eye disease. The gels were prepared using pluronic F-127 and either of chitosan, carbapol 971P, sodium alginate, or hydroxy propyl methyl cellulose. Drug-excipients compatibility was investigated by means of differential scanning calorimetry and Fourier transform infrared spectroscopy. The gels were characterized for pH, clarity, gelling capacity, viscosity, and adhesion. In vitro release of vitamin B12 from the selected gels was investigated. In vivo effectiveness of the selected gel was determined in rabbit models using Schirmer's and fluorescein tests. The compatibility studies revealed the possibility of incidence of drug/polymer interaction in some formulations. F2-containing pluronic F127 and hydroxypropyl methyl cellulose showed the most appropriate physical characterization and in vitro release profile. The prepared gels showed prolonged drug release with drug release mechanism of combined diffusion and erosion. The in vivo study revealed good effectiveness of the prepared mucoadhesive in situ gel system of vitamin B12 in the treatment of dry eye disease that was comparable to that of the marketed drops.

Indexed as

AdhesivesAnimalsDrug CompoundingDrug Delivery SystemsDrug LiberationDry Eye SyndromesExcipientsFemaleGelsHypromellose DerivativesMaleMucous MembranePoloxamerRabbitsViscosityVitamin B 12AdhesivesExcipientsGelsHypromellose DerivativesPoloxamerVitamin B 12VitaminsDry eyeIn situ gelSchirmer’s testVitamin B12

Identifiers

PMID33665761
OpenAlexW3135751630

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.