ArticleMolecules (Basel, Switzerland)2021
Proteomics Approach of Rapamycin Anti-Tumoral Effect on Primary and Metastatic Canine Mammary Tumor Cells In Vitro.
Patrícia F Lainetti, Antonio F Leis-Filho, Priscila E Kobayashi, Laíza S de Camargo, Renee Laufer-Amorim, Carlos E Fonseca-Alves, Fabiana F Souza
Open access · goldAbstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 4 citations in OpenAlex.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
7 authors at 2 institutions in 1 country.
Patrícia F LainettiDepartment of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, São Paulo State University-UNESP, Botucatu 18618-681, Brazil.
Antonio F Leis-FilhoDepartment of Veterinary Clinic, School of Veterinary Medicine and Animal Science, São Paulo State University-UNESP, Botucatu 18618-681, Brazil.
Priscila E KobayashiDepartment of Veterinary Clinic, School of Veterinary Medicine and Animal Science, São Paulo State University-UNESP, Botucatu 18618-681, Brazil.
Laíza S de CamargoDepartment of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, São Paulo State University-UNESP, Botucatu 18618-681, Brazil.
Renee Laufer-AmorimDepartment of Veterinary Clinic, School of Veterinary Medicine and Animal Science, São Paulo State University-UNESP, Botucatu 18618-681, Brazil.
Carlos E Fonseca-AlvesDepartment of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, São Paulo State University-UNESP, Botucatu 18618-681, Brazil.ORCID 0000-0002-6702-6139 Fabiana F SouzaDepartment of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, São Paulo State University-UNESP, Botucatu 18618-681, Brazil.
Universidade Estadual Paulista (Unesp) · BRUniversidade Paulista · BR
Funding
Conselho Nacional de Desenvolvimento Científico e Tecnológico 422139/2018-1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/24079-1
6 · The paper itselfAbstract
Rapamycin is an antifungal drug with antitumor activity and acts inhibiting the mTOR complex. Due to drug antitumor potential, the aim of this study was to evaluate its effect on a preclinical model of primary mammary gland tumors and their metastases from female dogs. Four cell lines from our cell bank, two from primary canine mammary tumors (UNESP-CM1, UNESP-CM60) and two metastases (UNESP-MM1, and UNESP-MM4) were cultured in vitro and investigated for rapamycin IC
Indexed as
ProteomicsAdaptor Proteins, Signal TransducingAnimalsAntibiotics, AntineoplasticCell ProliferationCell SurvivalDogsDrug Screening Assays, AntitumorFemaleMammary Neoplasms, AnimalMass SpectrometryProto-Oncogene Proteins c-aktPTEN PhosphohydrolaseSirolimusTOR Serine-Threonine KinasesTumor Cells, CulturedAdaptor Proteins, Signal TransducingAntibiotics, AntineoplasticProto-Oncogene Proteins c-aktPTEN PhosphohydrolaseSirolimusTOR Serine-Threonine Kinasescell culturefemale dogneoplasiaprotein
Identifiers
PMID33668689
PMCPMC7956669
OpenAlexW3129446550
What Socratic holds
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LicenceCC BY
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