Evidence map›Paper›PMID 33669749›Full record

ReviewJournal of personalized medicine2021

Recent Advances in Integrative Multi-Omics Research in Breast and Ovarian Cancer.

Christen A Khella, Gaurav A Mehta, Rushabh N Mehta, Michael L Gatza

Open access · goldAbstract readReview
In one paragraph

Review in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Ovarian Cancer: Multi-Omics Data Integration.International journal of molecular sciences · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Cancers · 2021
    Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Christen A KhellaRutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA.ORCID 0000-0002-7464-8702
Gaurav A MehtaRutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA.ORCID 0000-0002-1634-1980
Rushabh N MehtaRutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA.
Michael L GatzaRutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA.ORCID 0000-0001-6796-7791
Rutgers, The State University of New Jersey · US

Funding

American Cancer Society RSG-19-160-01-TBECox Foundation for Cancer Research NAMacMillan Cancer Genetics Summer Undergraduate Research Fellowship NANew Jersey Commission for Cancer Research DCHS-20PPC-014New Jersey Commission for Cancer Research DHFS-19PPC-019NIH HHS CA166228V Foundation for Cancer Research V2016-013
6 · The paper itself

Abstract

The underlying molecular heterogeneity of cancer is responsible for the dynamic clinical landscape of this disease. The combination of genomic and proteomic alterations, including both inherited and acquired mutations, promotes tumor diversity and accounts for variable disease progression, therapeutic response, and clinical outcome. Recent advances in high-throughput proteogenomic profiling of tumor samples have resulted in the identification of novel oncogenic drivers, tumor suppressors, and signaling networks; biomarkers for the prediction of drug sensitivity and disease progression; and have contributed to the development of novel and more effective treatment strategies. In this review, we will focus on the impact of historical and recent advances in single platform and integrative proteogenomic studies in breast and ovarian cancer, which constitute two of the most lethal forms of cancer for women, and discuss the molecular similarities of these diseases, the impact of these findings on our understanding of tumor biology as well as the clinical applicability of these discoveries.

Indexed as

breastcancergenomicsovarianproteomics

Identifiers

PMID33669749
PMCPMC7922242
OpenAlexW3131071668

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.