Evidence map›Paper›PMID 33671878›Full record

ReviewJournal of personalized medicine2021

Blood Pressure Patterns in Patients with Parkinson's Disease: A Systematic Review.

Delia Tulbă, Liviu Cozma, Paul Bălănescu, Adrian Buzea, Cristian Băicuș, Bogdan Ovidiu Popescu

Open access · goldAbstract readReview
In one paragraph

Review in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Nighttime systolic blood pressure reduction rate and periventricular white matter hyperintensity were associated with cognitive function in Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  5. Redefining Non-Motor Symptoms in Parkinson's Disease.Journal of personalized medicine · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Approaches for treating cardiovascular symptoms in Parkinson's disease.Therapeutic advances in neurological disorders · 2025
    Review
  10. Article
  11. Article
  12. Abnormal Cerebrovascular Activity, Perfusion, and Glymphatic Clearance in Lewy Body Diseases.Movement disorders : official journal of the Movement Disorder Society · 2024
    Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Delia TulbăDepartment of Neurology, Colentina Clinical Hospital, 20125 Bucharest, Romania.
Liviu CozmaDepartment of Neurology, Colentina Clinical Hospital, 20125 Bucharest, Romania.
Paul BălănescuColentina-Research and Development Center, Colentina Clinical Hospital, 20125 Bucharest, Romania.
Adrian Buzea"Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.ORCID 0000-0002-3365-9149
Cristian BăicușColentina-Research and Development Center, Colentina Clinical Hospital, 20125 Bucharest, Romania.ORCID 0000-0002-7954-0098
Bogdan Ovidiu PopescuDepartment of Neurology, Colentina Clinical Hospital, 20125 Bucharest, Romania.ORCID 0000-0003-4826-2598
Carol Davila University of Medicine and Pharmacy · RO

Funding

Ministry of Education and Research, Romania 23PFE/17.10.2018Ministry of Education and Research, Romania PN 1N/2019_19.29.02.01
6 · The paper itself

Abstract

(1) Background: Cardiovascular autonomic dysfunction is a non-motor feature in Parkinson's disease with negative impact on functionality and life expectancy, prompting early detection and proper management. We aimed to describe the blood pressure patterns reported in patients with Parkinson's disease, as measured by 24-h ambulatory blood pressure monitoring. (2) Methods: We conducted a systematic search on the PubMed database. Studies enrolling patients with Parkinson's disease undergoing 24-h ambulatory blood pressure monitoring were included. Data regarding study population, Parkinson's disease course, vasoactive drugs, blood pressure profiles, and measurements were recorded. (3) Results: The search identified 172 studies. Forty studies eventually fulfilled the inclusion criteria, with 3090 patients enrolled. Abnormal blood pressure profiles were commonly encountered: high blood pressure in 38.13% of patients (938/2460), orthostatic hypotension in 38.68% (941/2433), supine hypertension in 27.76% (445/1603) and nocturnal hypertension in 38.91% (737/1894). Dipping status was also altered often, 40.46% of patients (477/1179) being reverse dippers and 35.67% (310/869) reduced dippers. All these patterns were correlated with negative clinical and imaging outcomes. (4) Conclusion: Patients with Parkinson's disease have significantly altered blood pressure patterns that carry a negative prognosis. Ambulatory blood pressure monitoring should be validated as a biomarker of PD-associated cardiovascular dysautonomia and a tool for assisting therapeutic interventions.

Indexed as

24-h ambulatory blood pressure monitoringarterial hypertensionblood pressure patternsdysautonomianocturnal hypertensionorthostatic hypotensionParkinson’s diseasereduced dippingreverse dippingsupine hypertension

Identifiers

PMID33671878
PMCPMC7918947
OpenAlexW3130333595

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.