Evidence map›Paper›PMID 33672413›Full record

ArticleGenes2021

Investigating the Adoption of Clinical Genomics in Australia. An Implementation Science Case Study.

Stephanie Best, Janet C Long, Clara Gaff, Jeffrey Braithwaite, Natalie Taylor

Open access · goldAbstract read
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Polygenic risk scores in the clinic: Health-system leaders and primary care providers weigh in.Genetics in medicine : official journal of the American College of Medical Genetics · 2025
    Article
  5. Article
  6. Navigating an Uninformative Genomic Test Result: A Practical Guide.Journal of paediatrics and child health · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Stephanie BestAustralian Institute of Health Innovation, Macquarie University, Sydney, NSW 2113, Australia.ORCID 0000-0002-1107-8976
Janet C LongAustralian Institute of Health Innovation, Macquarie University, Sydney, NSW 2113, Australia.
Clara GaffMelbourne Genomics Health Alliance, Walter and Eliza Hall Institute, Melbourne, VIC 3052, Australia.
Jeffrey BraithwaiteAustralian Institute of Health Innovation, Macquarie University, Sydney, NSW 2113, Australia.
Natalie TaylorCancer Research Division, Cancer Council New South Wales, Sydney, NSW 2011, Australia.
Macquarie University · AUMurdoch Children's Research Institute · AUThe University of Melbourne · AUThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the overwhelming interest in clinical genomics, uptake has been slow. Implementation science offers a systematic approach to reveal pathways to adoption and a theory informed approach to addressing barriers presented. Using case study methodology, we undertook 16 in-depth interviews with nongenetic medical specialists to identify barriers and enablers to the uptake of clinical genomics. Data collection and analysis was guided by two evidence-based behaviour change models: the Theoretical Domains Framework (TDF), and the Capability, Opportunity Motivation Behaviour model (COM-B). Our findings revealed the use of implementation science not only provided a theoretical structure to frame the study but also facilitated uncovering of traditionally difficult to access responses from participants, e.g., "safety in feeling vulnerable" (TDF code

Indexed as

GenomicsImplementation ScienceAustraliaEmotionsFemaleHumansMaleMotivationclinical genomicsCOM.Bimplementation scienceTheoretical Domains Framework

Identifiers

PMID33672413
PMCPMC7926693
OpenAlexW3130875014

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.