Evidence map›Paper›PMID 33672866›Full record

ArticleInternational journal of molecular sciences2021

Loliolide, a New Therapeutic Option for Neurological Diseases? In Vitro Neuroprotective and Anti-Inflammatory Activities of a Monoterpenoid Lactone Isolated from

Joana Silva, Celso Alves, Alice Martins, Patrícia Susano, Marco Simões, Miguel Guedes, Stephanie Rehfeldt, Susete Pinteus, Helena Gaspar, Américo Rodrigues and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 70 citations in OpenAlex.

  1. Article
  2. Article
  3. Phenolic and Terpenic Composition ofPlants (Basel, Switzerland) · 2026
    Article
  4. Article
  5. Review
  6. Bioactive Sulfated Polysaccharides from Green AlgaeInternational journal of molecular sciences · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Molecules (Basel, Switzerland) · 2025
    Article
  12. International journal of molecular sciences · 2025
    Article
  13. Current Perspectives in Detection of Bioactive Compounds FromBiochemistry research international · 2025
    Article
  14. Identification ofFrontiers in microbiology · 2025
    Article
  15. Protective Effects ofJournal of microbiology and biotechnology · 2024
    Article
  16. Article
  17. Green Synthesis ofBiomolecules · 2024
    Article
  18. Monoterpene Hydroxy Lactones Isolated fromMolecules (Basel, Switzerland) · 2024
    Article
  19. Article
  20. IL-6 Inhibitory Compounds from the Aerial Parts ofMolecules (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Joana SilvaMARE-Marine and Environmental Sciences Centre, Polytechnic of Leiria, 2520-630 Peniche, Portugal.ORCID 0000-0003-1224-1699
Celso AlvesMARE-Marine and Environmental Sciences Centre, Polytechnic of Leiria, 2520-630 Peniche, Portugal.ORCID 0000-0003-1581-2127
Alice MartinsMARE-Marine and Environmental Sciences Centre, Polytechnic of Leiria, 2520-630 Peniche, Portugal.
Patrícia SusanoMARE-Marine and Environmental Sciences Centre, Polytechnic of Leiria, 2520-630 Peniche, Portugal.
Marco SimõesMARE-Marine and Environmental Sciences Centre, Polytechnic of Leiria, 2520-630 Peniche, Portugal.ORCID 0000-0001-7995-7304
Miguel GuedesMARE-Marine and Environmental Sciences Centre, Polytechnic of Leiria, 2520-630 Peniche, Portugal.ORCID 0000-0002-1646-7364
Stephanie RehfeldtCell Culture Laboratory, Graduate Program in Biotechnology, University of Vale do Taquari (Univates), Lajeado, RS 95914-014, Brazil.ORCID 0000-0002-0362-3129
Susete PinteusMARE-Marine and Environmental Sciences Centre, Polytechnic of Leiria, 2520-630 Peniche, Portugal.ORCID 0000-0002-3290-3111
Helena GasparBioISI-Biosystems and Integrative Sciences Institute, Faculty of Sciences, University of Lisbon, 1749-016 Lisboa, Portugal.ORCID 0000-0002-1613-7023
Américo RodriguesMARE-Marine and Environmental Sciences Centre, Polytechnic of Leiria, 2520-630 Peniche, Portugal.
Márcia Ines GoettertCell Culture Laboratory, Graduate Program in Biotechnology, University of Vale do Taquari (Univates), Lajeado, RS 95914-014, Brazil.ORCID 0000-0002-3648-5033
Amparo AlfonsoDepartment of Pharmacology, Faculty of Veterinary, University of Santiago de Compostela, 27002 Lugo, Spain.ORCID 0000-0003-1572-9016
Rui PedrosaMARE-Marine and Environmental Sciences Centre, ESTM, Polytechnic of Leiria, 2520-614 Peniche, Portugal.
Instituto Politécnico de Leiria · PTUnivates · BRUniversidade de Santiago de Compostela · ESUniversity of Lisbon · PT

Funding

European Regional Development Fund Centro-01-0145-FEDER-000018European Regional Development Fund PTDC/ BIA-BQM/28355/2017Fundação para a Ciência e a Tecnologia PTDC/ BIA-BQM/28355/2017Fundação para a Ciência e a Tecnologia PTDC/BIA-OUT/29250/2017Fundação para a Ciência e a Tecnologia SFRH/BD/103255/2014Fundação para a Ciência e a Tecnologia UID/04292/2020Fundação para a Ciência e a Tecnologia UIDB/04046/2020Fundação para a Ciência e a Tecnologia UIDP/04046/2020Programa Operacional Regional do Centro POCI-01-0145-FEDER-029250
6 · The paper itself

Abstract

Parkinsons Disease (PD) is the second most common neurodegenerative disease worldwide, and is characterized by a progressive degeneration of dopaminergic neurons. Without an effective treatment, it is crucial to find new therapeutic options to fight the neurodegenerative process, which may arise from marine resources. Accordingly, the goal of the present work was to evaluate the ability of the monoterpenoid lactone Loliolide, isolated from the green seaweed

Indexed as

AnimalsAnti-Inflammatory AgentsBenzofuransCell Line, TumorChlorophytaCytokinesDNA FragmentationHumansLactonesMacrophagesMembrane Potential, MitochondrialMiceMolecular StructureMonoterpenesNeurodegenerative DiseasesNeuroprotective AgentsAnti-Inflammatory AgentsBenzofuransCytokinesLactonesloliolideMonoterpenesNeuroprotective AgentsNF-kappa BNitric OxideReactive Oxygen Speciesantioxidant activityinflammationmarine natural productsneuroprotectionNF-kB pathwayoxidative stressParkinson’s diseaseseaweeds

Identifiers

PMID33672866
PMCPMC7918146
OpenAlexW3130184083

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.