ArticleBiosensors2021
Noninvasive Monitoring of Glucose Using Near-Infrared Reflection Spectroscopy of Skin-Constraints and Effective Novel Strategy in Multivariate Calibration.
Article in Biosensors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- Non-Invasive Technologies in Wearable Glucose Monitoring: A Structured Overview for the Future.Biosensors · 2026Review
- Optical convolutional spectrometer.Nature photonics · 2026Article
- Advancing the Development of Subcutaneous Glucose Biosensors: Cargo-Carrying Adhesive Biosensor Systems (CABs).Macromolecular bioscience · 2026Article
- Noninvasive Continuous Glucose Monitoring Using Multimodal Near-Infrared, Temperature, and Pressure Signals on the Earlobe.Biosensors · 2025Article
- A low-power approach to optical glucose sensing via polarisation switching.Scientific reports · 2025Article
- Effects of Skin Blood Flow Fluctuations on Non-Invasive Glucose Measurement and a Feasible Blood Flow Control Method.Sensors (Basel, Switzerland) · 2025Article
- A comprehensive review on electromagnetic wave based non-invasive glucose monitoring in microwave frequencies.Heliyon · 2024Review
- Article
- Development of sensor system and data analytic framework for non-invasive blood glucose prediction.Scientific reports · 2024Article
- Non-Invasive Glucose Sensing Technologies and Products: A Comprehensive Review for Researchers and Clinicians.Sensors (Basel, Switzerland) · 2023Review
- Article
- [Research progress on minimally invasive and non-invasive blood glucose detection methods].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2023Article
- Quantification of glycated hemoglobin and glucose in vivo using Raman spectroscopy and artificial neural networks.Lasers in medical science · 2022Article
- Review of Ethanol Intoxication Sensing Technologies and Techniques.Sensors (Basel, Switzerland) · 2022Review
- Photonic Biosensors: Detection, Analysis and Medical Diagnostics.Biosensors · 2022Article
- Is Raman the best strategy towards the development of non-invasive continuous glucose monitoring devices for diabetes management?Frontiers in chemistry · 2022Review
- Products for Monitoring Glucose Levels in the Human Body With Noninvasive Optical, Noninvasive Fluid Sampling, or Minimally Invasive Technologies.Journal of diabetes science and technology · 2022Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
For many years, successful noninvasive blood glucose monitoring assays have been announced, among which near-infrared (NIR) spectroscopy of skin is a promising analytical method. Owing to the tiny absorption bands of the glucose buried among a dominating variable spectral background, multivariate calibration is required to achieve applicability for blood glucose self-monitoring. The most useful spectral range with important analyte fingerprint signatures is the NIR spectral interval containing combination and overtone vibration band regions. A strategy called science-based calibration (SBC) has been developed that relies on a priori information of the glucose signal ("response spectrum") and the spectral noise, i.e., estimates of the variance of a sample population with negligible glucose dynamics. For the SBC method using transcutaneous reflection skin spectra, the response spectrum requires scaling due to the wavelength-dependent photon penetration depth, as obtained by Monte Carlo simulations of photon migration based on estimates of optical tissue constants. Results for tissue glucose concentrations are presented using lip NIR-spectra of a type-1 diabetic subject recorded under modified oral glucose tolerance test (OGTT) conditions. The results from the SBC method are extremely promising, as statistical calibrations show limitations under the conditions of ill-posed equation systems as experienced for tissue measurements. The temporal profile differences between the glucose concentration in blood and skin tissue were discussed in detail but needed to be further evaluated.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.