ArticleScience (New York, N.Y.)2021
Combined liver-cytokine humanization comes to the rescue of circulating human red blood cells.
Open access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- The Coming of Age of Preclinical Models of MDS.Frontiers in oncology · 2022Pooled it
- Deceiving HIV: Engineered erythrocytes as cellular decoys.Molecular therapy. Advances · 2026Article
- Reverse genetics in humanized mice reveals CARD8-mediated pyroptosis causing pancytopenia in human DPP9 deficiency.The Journal of clinical investigation · 2026Article
- The making of cells and organs in xenogeneic animal bioreactor.Signal transduction and targeted therapy · 2026Review
- Reverse genetics in humanized mice reveals CARD8-mediated pyroptosis causing pancytopenia in human DPP9 deficiency.bioRxiv : the preprint server for biology · 2026Article
- Recent advances in the construction of humanized animal models and applications in translational medicine.Animal models and experimental medicine · 2026Review
- Tracing the in vivo behavior of nucleated cultured red blood cells generated from hematopoietic stem and progenitor cells.Stem cell research & therapy · 2026Article
- Functional xenogeneic hematopoietic cells maintaining donor-dominant identity and immune tolerance enable therapy.Experimental hematology & oncology · 2026Article
- Humanization of CD47 enables development of functional human neutrophils via postirradiation remodeling of the bone marrow.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Understanding erythroid physiology and pathology in humanized mice: A closer look.British journal of haematology · 2025Review
- Recent Advances in Membrane-Coated Micro/Nanomotors in Biological Applications.International journal of nanomedicine · 2025Review
- Peripheral human red blood cell development in human immune system mouse model with heme oxygenase-1 deficiency.Blood advances · 2024Article
- Mice Engrafted with Human Liver Cells.Seminars in liver disease · 2024Review
- Small-molecule α-lipoic acid targets ELK1 to balance human neutrophil and erythrocyte differentiation.Stem cell research & therapy · 2024Article
- From NAFLD to MASLD: implications of the new nomenclature for preclinical and clinical research.Nature metabolism · 2024Article
- A Monocytic Barrier to the Humanization of Immunodeficient Mice.Current stem cell research & therapy · 2024Review
- Learning human liver biology in humanized mice.Cell research · 2024Article
- Microenvironment-dependent growth of Sezary cells in humanized IL-15 mice.Disease models & mechanisms · 2023Article
- Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions.Cell · 2023Article
- Modeling the Tumor Microenvironment and Cancer Immunotherapy in Next-Generation Humanized Mice.Cancers · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 6 institutions in 4 countries.
Yuanbin Song *Section of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0001-5580-5998
Liang Shan *Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. liang.shan@wustl.edu stephanie.halene@yale.edu richard.flavell@yale.edu.ORCID https://orcid.org/0000-0002-8833-2514
Rana Gbyli *Section of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.
Wei LiuSection of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.
Till StrowigDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0003-0185-1459
Amisha PatelSection of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.
Xiaoying FuSection of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0003-4210-3510
Xiaman WangSection of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0001-5046-5664
Mina L XuDepartment of Pathology, Yale University School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0001-9513-245X
Yimeng GaoSection of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0003-2954-2789
Ashley QinSection of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0002-3124-8872
Emanuela M BrusciaDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0003-2149-4057
Toma TebaldiSection of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0002-0625-1631
Giulia BianconSection of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0003-0182-7766
Padmavathi MamillapalliSection of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.
David UrbonasDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0001-7390-2564
Elizabeth EynonDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0003-0638-6306
David G GonzalezDepartment of Genetics, Yale University School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0002-0106-6461
Jie ChenDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0002-5790-1606
Diane S KrauseYale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA.
Jonathan AldermanDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Stephanie Halene *Section of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA. liang.shan@wustl.edu stephanie.halene@yale.edu richard.flavell@yale.edu.ORCID https://orcid.org/0000-0002-2737-9810
Richard A Flavell *Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. liang.shan@wustl.edu stephanie.halene@yale.edu richard.flavell@yale.edu.ORCID https://orcid.org/0000-0003-4461-0778
Yale Cancer Center · USYale University · USHoward Hughes Medical Institute · USSun Yat-sen University · CNUniversity of Trento · ITWashington University in St. Louis · US
Funding
Yale Cooperative Hematology Specialized Core CenterU54DK106857 · NIDDK · YALE UNIVERSITY · PI JOHN HWA, Diane S Krause · 2015 to 2026
$9.7MThe role of mutant splicing factor SRSF2 in MyelodysplasiaR01DK102792 · NIDDK · YALE UNIVERSITY · PI HALENE, STEPHANIE · 2016 to 2019
$1.5MDeveloping humanized mouse models for the study of HIV-1 latency and viral eradicationK99AI125065 · NIAID · YALE UNIVERSITY · PI SHAN, LIANG · 2016 to 2016
$133kHoward Hughes Medical InstituteNIAID NIH HHS K99 AI125065NIDDK NIH HHS R01 DK102792NIDDK NIH HHS U54 DK106857
Abstract
In vivo models that recapitulate human erythropoiesis with persistence of circulating red blood cells (RBCs) have remained elusive. We report an immunodeficient murine model in which combined human liver and cytokine humanization confer enhanced human erythropoiesis and RBC survival in the circulation. We deleted the fumarylacetoacetate hydrolase (
Indexed as
Blood CirculationDisease Models, AnimalMiceAnemia, Sickle CellAnimalsCytokinesErythrocytesErythropoiesisFemaleGene DeletionHematopoietic Stem CellsHumansHydrolasesLiverMice, Mutant StrainsMiddle AgedCytokinesfumarylacetoacetaseHydrolases
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What Socratic holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.