Evidence map›Paper›PMID 33676499›Full record

Observational studyCardiovascular diabetology2021

Clinical profiles and quality of care of subjects with type 2 diabetes according to their cardiovascular risk: an observational, retrospective study.

Basilio Pintaudi, Alessia Scatena, Gabriella Piscitelli, Vera Frison, Salvatore Corrao, Valeria Manicardi, Giusi Graziano, Maria Chiara Rossi, Marco Gallo, Domenico Mannino and 2 more

Open access · goldAbstract readComparative StudyObservational Study
In one paragraph

Observational study in Cardiovascular diabetology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
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  8. Effectiveness and Safety of iGlarLixi in People with Type 2 Diabetes in Adriatic Region Countries: ENSURE-ADR, a Real-World Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2023
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  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 1 country.

Basilio PintaudiDiabetes Unit, Niguarda Cà Granda Hospital, Milan, Italy.
Alessia ScatenaSan Donato Hospital, Arezzo, Italy.
Gabriella PiscitelliDiabetology, ASST Nord Milan, Sesto San Giovanni, Italy.
Vera FrisonInternal Medicine and Diabetology Service, ULSS6, Cittadella, Italy.
Salvatore CorraoDepartment of Internal Medicine, ARNAS Civico Benfratelli Hospital, University of Palermo, Palermo, Italy.
Valeria ManicardiDiabetes Clinic, Azienda USL-IRCCS Di Reggio Emilia, Reggio Emilia, Italy.
Giusi GrazianoCenter for Outcomes Research and Clinical Epidemiology, CORESEARCH, Corso Umberto I, 65122, Pescara, Italy.
Maria Chiara RossiCenter for Outcomes Research and Clinical Epidemiology, CORESEARCH, Corso Umberto I, 65122, Pescara, Italy.
Marco GalloAOU Città Della Salute E Della Scienza, Presidio Ospedaliero Molinette, Torino, Italy.
Domenico ManninoEndocrinology and Metabolic Unit, GOM, Reggio Calabria, Italy.
Paolo Di BartoloAUSL Diabetes Unit Romagna, Ravenna, Italy.
Antonio NicolucciCenter for Outcomes Research and Clinical Epidemiology, CORESEARCH, Corso Umberto I, 65122, Pescara, Italy. nicolucci@coresearch.it.ORCID 0000-0002-5939-6850
Center for Outcomes Research and Clinical Epidemiology · ITAzienda Sanitaria Unità Locale di Reggio Emilia · ITAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITAzienda Unità Sanitaria Locale Della Romagna · ITMilano Metropoli Development Agency · ITOspedale San Donato · ITPresidio Ospedaliero · ITUniversity of Palermo · ITUniversity of Reggio Calabria · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe European Society of Cardiology (ESC) recently defined cardiovascular risk classes for subjects with diabetes. Aim of this study was to explore the distribution of subjects with type 2 diabetes (T2D) by cardiovascular risk groups according to the ESC classification and to describe the quality indicators of care, with particular regard to cardiovascular risk factors.

methodsThe study is based on data extracted from electronic medical records of patients treated at the 258 Italian diabetes centers participating in the AMD Annals initiative. Patients with T2D were stratified by cardiovascular risk. General descriptive indicators, measures of intermediate outcomes, intensity/appropriateness of pharmacological treatment for diabetes and cardiovascular risk factors, presence of other complications and overall quality of care were evaluated.

resultsOverall, 473,740 subjects with type 2 diabetes (78.5% at very high cardiovascular risk, 20.9% at high risk and 0.6% at moderate risk) were evaluated. Among people with T2D at very high risk: 26.4% had retinopathy, 39.5% had albuminuria, 18.7% had a previous major cardiovascular event, 39.0% had organ damage, 89.1% had three or more risk factors. The use of DPP4-i markedly increased as cardiovascular risk increased. The prescription of secretagogues also increased and that of GLP1-RAs tended to increase. The use of SGLT2-i was still limited, and only slightly higher in subjects with very high cardiovascular risk. The overall quality of care, as summarized by the Q score, tended to be lower as the level of cardiovascular risk increased.

conclusionsA large proportion of subjects with T2D is at high or very high risk. Glucose-lowering drug therapies seem not to be adequately used with respect to their potential advantages in terms of cardiovascular risk reduction. Several actions are necessary to improve the quality of care.

Indexed as

Quality Indicators, Health CareAdultAgedAged, 80 and overBiomarkersBlood GlucoseCardiovascular DiseasesDiabetes Mellitus, Type 2Dipeptidyl-Peptidase IV InhibitorsElectronic Health RecordsFemaleHeart Disease Risk FactorsHumansHypoglycemic AgentsIncretinsItalyBiomarkersBlood GlucoseDipeptidyl-Peptidase IV InhibitorsHypoglycemic AgentsIncretinsSodium-Glucose Transporter 2 InhibitorsCardiovascular riskQuality of careType 2 diabetes

Identifiers

PMID33676499
PMCPMC7936493
OpenAlexW3133770873

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.