Evidence map›Paper›PMID 33679216›Full record

ArticleThe Malaysian journal of medical sciences : MJMS2021

Analysis of K

Mohd Harizal Senik, Izuddin Fahmy Abu, Widad Fadhullah

Open access · diamondAbstract read
In one paragraph

Article in The Malaysian journal of medical sciences : MJMS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 64% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Mohd Harizal SenikDepartment of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.
Izuddin Fahmy AbuInstitute of Medical Science Technology, Universiti Kuala Lumpur, Kuala Lumpur, Malaysia.
Widad FadhullahSchool of Industrial Technology, Universiti Sains Malaysia, Pulau Pinang, Malaysia.
Universiti Sains Malaysia · MYUniversity of Kuala Lumpur · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKainic acid (KA)-induced seizures may be a valuable tool in the assessment of anti-epileptic drug efficacy in complex partial seizures. This study investigated the effects of KA on ATP-sensitive K

methodsFor the optimisation and validation protocol, β-cells were plated onto 35 mm plastic petri dishes and maintained in RPMI-1640 media supplemented with 10 mM glucose, 10% FCS and 25 mM of N-2-hydroxyethylpiperazine-N-ethanesulfonic acid (HEPES). The treatment effects of 10 mM glucose and 30 μM fluoxetine on K

resultsNPo of β-cells showed significant decreasing patterns (

conclusionThe two concentrations of KA used in the study exerted contrasting effects toward the mean of NPo. It is hypothesised that KA at lower concentration (1 mM) opens more K

Indexed as

channel opening probabilityepilepsyhippocampus cellsKainic acidKATP channelspancreatic beta-cellspotassium channel

Identifiers

PMID33679216
PMCPMC7909348
OpenAlexW3129455398

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.