Evidence mapPaperPMID 33679779Full record

SynthesisFrontiers in immunology2021

Adjunct Therapy for CD4

Yang Zhang, Taiyi Jiang, Aixin Li, Zhen Li, Jianhua Hou, Meixia Gao, Xiaojie Huang, Bin Su, Hao Wu, Tong Zhang and 1 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. High dose of rifampicin in the treatment of tuberculous meningitis: a systematic review and meta-analysis of randomized controlled trials.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Viruses · 2025
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Pathological proliferation: a potential mechanism for poor CD4Frontiers in cellular and infection microbiology · 2024
    Article
  17. Article
  18. Article
  19. Elevated Foxp3Frontiers in immunology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Yang ZhangCenter for Infectious Diseases, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
Taiyi JiangCenter for Infectious Diseases, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
Aixin LiCenter for Infectious Diseases, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
Zhen LiCenter for Infectious Diseases, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
Jianhua HouCenter for Infectious Diseases, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
Meixia GaoCenter for Infectious Diseases, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
Xiaojie HuangCenter for Infectious Diseases, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
Bin SuCenter for Infectious Diseases, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
Hao WuCenter for Infectious Diseases, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
Tong ZhangCenter for Infectious Diseases, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
Wei JiangDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, United States.
Capital Medical University · CNBeijing YouAn Hospital · CNMedical University of South Carolina · US

Funding

NIAID NIH HHS R01 AI128864
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

HIV Long-Term SurvivorsCD4-Positive T-LymphocytesHIV-1HIV InfectionsHumansImmunityImmunomodulationInflammationadjunct therapyCD4+ T-cellimmune activationimmunologic non-responderinflammationpeople living with HIV

Identifiers

PMID33679779
PMCPMC7925844
OpenAlexW3129815729

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.