Evidence map›Paper›PMID 33682296›Full record

ArticleVeterinary ophthalmology2021

Presumed neuroprotective therapies prescribed by veterinary ophthalmologists for canine degenerative retinal and optic nerve diseases.

Ryan G Hopper, Fabiano Montiani-Ferreira, Jorge da Silva Pereira, Michele C Fritz, Vickie J Ruggiero, John S Sapienza, Kumiko Kato, András M Komáromy

Open access · greenAbstract read
In one paragraph

Article in Veterinary ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Role of Inflammation in Canine Primary Glaucoma.Animals : an open access journal from MDPI · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Ryan G HopperDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA.
Fabiano Montiani-FerreiraDepartment of Veterinary Medicine, Federal University of Paraná, Curitiba, Paraná, Brazil.ORCID https://orcid.org/0000-0002-3933-8864
Jorge da Silva PereiraCenter of Studies, Research, and Veterinary Ophthalmology (CEPOV), Rio de Janeiro, Brazil.
Michele C FritzOffice of Academic Programs, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA.
Vickie J RuggieroOffice of Academic Programs, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA.
John S SapienzaLong Island Veterinary Specialists, Plainview, NY, USA.
Kumiko KatoKumi Animal Hospital, Misato-city, Japan.
András M KomáromyDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA.ORCID https://orcid.org/0000-0002-8845-0588
Michigan State University · USCarolina Veterinary Specialists · USKumamoto City Hospital · JPUniversidade Federal do Paraná · BR

Funding

Therapy development for open-angle glaucomasR01EY025752 · NEI · MICHIGAN STATE UNIVERSITY · PI KOMAROMY, ANDRAS · 2017 to 2021
$3.2M
Short-term biomedical research training program for veterinary studentsT35OD016477 · OD · MICHIGAN STATE UNIVERSITY · PI COLLEEN Cosgrove HEGG, Andrea Noel Johnston · 2013 to 2026
$1.5M
NEI NIH HHS R01 EY025752NIH HHS R01-EY025752NIH HHS T35 OD016477NIH HHS T35-OD016477
6 · The paper itself

Abstract

objectiveTo investigate veterinary ophthalmologists' use of presumed neuroprotective therapies for degenerative retinal and optic nerve diseases in dogs. PROCEDURES: An online survey was sent to 663 board-certified veterinary ophthalmologists who were Diplomates of the American College of Veterinary Ophthalmologists (ACVO), Asian College of Veterinary Ophthalmologists (AiCVO), Latin American College of Veterinary Ophthalmologists (Colegio Latinoamericano de Oftalmólogos Veterinarios, CLOVE), or European College of Veterinary Ophthalmologists (ECVO). The survey was created using Qualtrics® software and focused on the prescription of presumed neuroprotective treatments for canine glaucoma, sudden acquired retinal degeneration syndrome (SARDS), progressive retinal atrophy (PRA), and retinal detachment (RD).

resultsA total of 165 completed surveys were received, representing an overall response rate of 25%, which was comparable across the four specialty colleges. Of all respondents, 140/165 (85%) prescribed some form of presumed neuroprotective therapies at least once in the last five years: 114/165 (69%) for glaucoma, 51/165 (31%) for SARDS, 116/165 (70%) for PRA, and 50/165 (30%) for RD. The three most recommended neuroprotective reagents were the commercial Ocu-GLO™ Vision Supplement for animals, amlodipine, and human eye supplements.

conclusionsDespite lack of published clinical efficacy data, the majority of surveyed board-certified veterinary ophthalmologists previously prescribed a presumed neuroprotective therapy at least once in the last five years in dogs with degenerative retinal and optic nerve diseases.

Indexed as

OphthalmologistsVeterinariansAnimalsAsiaDog DiseasesDogsEuropeLatin AmericaNeuroprotective AgentsOptic Nerve DiseasesPractice Patterns, Physicians'Retinal DegenerationSurveys and QuestionnairesUnited StatesNeuroprotective Agentscanineglaucomaneuroprotectionprogressive retinal atrophyretinal detachmentsudden acquired retinal degeneration syndrome

Identifiers

PMID33682296
PMCPMC8137575
OpenAlexW3134747669

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.