Evidence map›Paper›PMID 33682565›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2021

The development of novel cytochrome P450 2J2 (CYP2J2) inhibitor and the underlying interaction between inhibitor and CYP2J2.

Xiangge Tian, Meirong Zhou, Jing Ning, Xiaopeng Deng, Lei Feng, Huilian Huang, Dahong Yao, Xiaochi Ma

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Xiangge TianLaboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Meirong ZhouLaboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Jing NingDalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, Dalian Medical University, Dalian, China.
Xiaopeng DengLaboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Lei FengDalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, Dalian Medical University, Dalian, China.
Huilian HuangLaboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Dahong YaoSchool of Pharmaceutical Sciences, Shenzhen Technology University, Shenzhen, China.
Xiaochi MaLaboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Jiangxi University of Traditional Chinese Medicine · CNDalian Medical University · CNShenzhen Technology University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human Cytochrome P450 2J2 (CYP2J2) as an important metabolic enzyme, plays a crucial role in metabolism of polyunsaturated fatty acids (PUFAs). Elevated levels of CYP2J2 have been associated with various types of cancer, and therefore it serves as a potential drug target. Herein, using a high-throughput screening approach based on enzymic activity of CYP2J2, we rapidly and effectively identified a novel natural inhibitor (Piperine,

Indexed as

Drug DevelopmentAlkaloidsBenzodioxolesCytochrome P-450 CYP2J2Cytochrome P-450 Enzyme InhibitorsCytochrome P-450 Enzyme SystemDose-Response Relationship, DrugHigh-Throughput Screening AssaysHumansModels, MolecularMolecular StructurePiperidinesPolyunsaturated AlkamidesRecombinant ProteinsStructure-Activity RelationshipAlkaloidsBenzodioxolesCYP2J2 protein, humanCytochrome P-450 CYP2J2Cytochrome P-450 Enzyme InhibitorsCytochrome P-450 Enzyme SystemPiperidinespiperinePolyunsaturated AlkamidesRecombinant ProteinsCYP2J2docking and molecular dynamicshigh-throughput screening approachinhibition kineticPiperinestructural modification

Identifiers

PMID33682565
PMCPMC7946002
OpenAlexW3135349744

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.