Evidence map›Paper›PMID 33684131›Full record

Trial reportPloS one2021

Genotypes and phylogenetic analysis of adenovirus in children with respiratory infection in Buenos Aires, Argentina (2000-2018).

Débora N Marcone, Andrés C A Culasso, Noelia Reyes, Adriana Kajon, Diana Viale, Rodolfo H Campos, Guadalupe Carballal, Marcela Echavarria

Open access · goldAbstract readClinical Trial
In one paragraph

Trial report in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Débora N MarconeUnidad de Virología, Centro de Educación Médica e Investigaciones Clínicas (CEMIC) Hospital Universitario, Ciudad de Buenos Aires, Argentina.ORCID 0000-0003-4407-7280
Andrés C A CulassoDepartamento de Microbiología, Inmunología y Biotecnología, Cátedra de Virología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina.
Noelia ReyesUnidad de Virología, Centro de Educación Médica e Investigaciones Clínicas (CEMIC) Hospital Universitario, Ciudad de Buenos Aires, Argentina.
Adriana KajonInfectious Disease Program, Lovelace Respiratory Research Institute, Albuquerque, NM, United States of America.
Diana VialeDepartamento de Microbiología, Hospital Prof. Dr. Juan P. Garrahan, Ciudad de Buenos Aires, Argentina.
Rodolfo H CamposDepartamento de Microbiología, Inmunología y Biotecnología, Cátedra de Virología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina.
Guadalupe CarballalUnidad de Virología, Centro de Educación Médica e Investigaciones Clínicas (CEMIC) Hospital Universitario, Ciudad de Buenos Aires, Argentina.
Marcela EchavarriaUnidad de Virología, Centro de Educación Médica e Investigaciones Clínicas (CEMIC) Hospital Universitario, Ciudad de Buenos Aires, Argentina.
Consejo Nacional de Investigaciones Científicas y Técnicas · ARCentro de Educación Médica e Investigaciones Clínicas Norberto Quirno · ARGarrahan Hospital · ARLovelace Respiratory Research Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human adenoviruses (HAdV) are one of the most frequent causes of respiratory infections around the world, causing mild to severe disease. In Argentina, many studies focused on the association of HAdV respiratory infection with severe disease and fatal outcomes leading to the discovery in 1984 of a genomic variant 7h associated with high fatality. Although several molecular studies reported the presence of at least 4 HAdV species (B, C, D and E) in Argentina, few sequences were available in the databases. In this study, sequences from the hexon gene region were obtained from 141 patients as a first approach to assess the genetic diversity of HAdVs circulating in Buenos Aires, Argentina. Phylogenetic analysis of these sequences and others recovered from public databases confirmed the circulation of the four above-mentioned species represented by 11 genotypes, with predominance in species B and C and shifts in their proportion in the studied period (2000 to 2018). The variants detected in Argentina, for most of the genotypes, were similar to those already described in other countries. However, uncommon lineages belonging to genotypes C2, C5 and E4 were detected, which might indicate the circulation of local variants and will deserve further studies of whole-genome sequences.

Indexed as

Databases, Nucleic AcidGenotypePhylogenyAdenoviruses, HumanAdenovirus Infections, HumanArgentinaChildChild, PreschoolFemaleHumansInfantMaleRespiratory Tract InfectionsSequence Analysis, DNA

Identifiers

PMID33684131
PMCPMC7939361
OpenAlexW3135809725

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.