ArticleBMC genomics2021
An intriguing characteristic of enhancer-promoter interactions.
Article in BMC genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- The 3D genome and its impacts on human health and disease.Life medicine · 2023Review
- A systematic study of motif pairs that may facilitate enhancer-promoter interactions.Journal of integrative bioinformatics · 2022Article
- Master lineage transcription factors anchor trans mega transcriptional complexes at highly accessible enhancer sites to promote long-range chromatin clustering and transcription of distal target genes.Nucleic acids research · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundIt is still challenging to predict interacting enhancer-promoter pairs (IEPs), partially because of our limited understanding of their characteristics. To understand IEPs better, here we studied the IEPs in nine cell lines and nine primary cell types.
resultsBy measuring the bipartite clustering coefficient of the graphs constructed from these experimentally supported IEPs, we observed that one enhancer is likely to interact with either none or all of the target genes of another enhancer. This observation implies that enhancers form clusters, and every enhancer in the same cluster synchronously interact with almost every member of a set of genes and only this set of genes. We perceived that an enhancer can be up to two megabase pairs away from other enhancers in the same cluster. We also noticed that although a fraction of these clusters of enhancers do overlap with super-enhancers, the majority of the enhancer clusters are different from the known super-enhancers.
conclusionsOur study showed a new characteristic of IEPs, which may shed new light on distal gene regulation and the identification of IEPs.
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Registered trials
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