Evidence map›Paper›PMID 33689276›Full record

ArticleACS infectious diseases2021

Violacein-Induced Chaperone System Collapse Underlies Multistage Antiplasmodial Activity.

Tatyana Almeida Tavella, Noeli Soares Melo da Silva, Natalie Spillman, Ana Carolina Andrade Vitor Kayano, Gustavo Capatti Cassiano, Adrielle Ayumi Vasconcelos, Antônio Pedro Camargo, Djane Clarys Baia da Silva, Diana Fontinha, Luis Carlos Salazar Alvarez and 16 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. HSP70 and their co-chaperones in the human malaria parasiteFrontiers in molecular biosciences · 2022
    Review
  6. Inhibitors of theCells · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 7 institutions in 4 countries.

Tatyana Almeida TavellaLaboratory of Tropical Diseases-Prof. Dr. Luiz Jacinto da Silva, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas-UNICAMP, Campinas, SP 13083-970, Brazil.
Noeli Soares Melo da SilvaBiochemistry and Biophysics of Proteins Group-São Carlos Institute of Chemistry-IQSC, University of São Paulo, Trabalhador Sancarlense Avenue, 400, BQ1, S27, São Carlos, SP 13566-590, Brazil.
Natalie SpillmanDepartment of Biochemistry, Bio 21 Institute, University of Melbourne, 30 Flemington Rd, Parkville, Melbourne,VIC 3052, Australia.
Ana Carolina Andrade Vitor KayanoLaboratory of Tropical Diseases-Prof. Dr. Luiz Jacinto da Silva, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas-UNICAMP, Campinas, SP 13083-970, Brazil.
Gustavo Capatti CassianoLaboratory of Tropical Diseases-Prof. Dr. Luiz Jacinto da Silva, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas-UNICAMP, Campinas, SP 13083-970, Brazil.
Adrielle Ayumi VasconcelosLaboratory of Genomics and BioEnergy, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas-UNICAMP, Campinas, SP 13083-970, Brazil.
Antônio Pedro CamargoLaboratory of Genomics and BioEnergy, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas-UNICAMP, Campinas, SP 13083-970, Brazil.
Djane Clarys Baia da SilvaLeônidas & Maria Deane Institute, Fundação Oswaldo Cruz-FIOCRUZ, Manaus , AM 69057070, Brazil.
Diana FontinhaInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-004 Lisboa, Portugal.
Luis Carlos Salazar AlvarezLaboratory of Tropical Diseases-Prof. Dr. Luiz Jacinto da Silva, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas-UNICAMP, Campinas, SP 13083-970, Brazil.
Letícia Tiburcio FerreiraLaboratory of Tropical Diseases-Prof. Dr. Luiz Jacinto da Silva, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas-UNICAMP, Campinas, SP 13083-970, Brazil.
Kaira Cristina Peralis TomazLaboratory of Tropical Diseases-Prof. Dr. Luiz Jacinto da Silva, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas-UNICAMP, Campinas, SP 13083-970, Brazil.
Bruno Junior NevesLaboratory of Molecular Modeling and Drug Design, LabMol, Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, GO 74605-170, Brazil.ORCID 0000-0002-1309-8743
Ludimila Dias AlmeidaSynthetic Biology Laboratory, Department of Structural and Functional Biology, Institute of Biology, UNICAMP, Campinas, SP Brazil.
Daniel Youssef BargieriDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, Cidade Universitária "Armando Salles Oliveira", São Paulo 05508-000, Brazil.
Marcus Vinicius Guimarães de LacerdaFundação de Medicina Tropical-Dr. Heitor Vieira Dourado, Manaus, AM 69040-000, Brazil.
Pedro Vitor Lemos CravoLabChem-Laboratory of Cheminformatics, Centro Universitário de Anápolis-UniEVANGÉLICA, Anápolis, GO 75083-515, Brazil.
Per SunnerhagenDepartment of Chemistry and Molecular Biology, University of Gothenburg, 405 30 Gothenburg, Sweden.ORCID 0000-0002-0967-8729
Miguel PrudêncioInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-004 Lisboa, Portugal.
Carolina Horta AndradeLaboratory of Tropical Diseases-Prof. Dr. Luiz Jacinto da Silva, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas-UNICAMP, Campinas, SP 13083-970, Brazil.
Stefanie Costa Pinto LopesLeônidas & Maria Deane Institute, Fundação Oswaldo Cruz-FIOCRUZ, Manaus , AM 69057070, Brazil.
Marcelo Falsarella CarazzolleLaboratory of Genomics and BioEnergy, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas-UNICAMP, Campinas, SP 13083-970, Brazil.
Leann TilleyDepartment of Biochemistry, Bio 21 Institute, University of Melbourne, 30 Flemington Rd, Parkville, Melbourne,VIC 3052, Australia.ORCID 0000-0001-9910-0199
Elizabeth BilslandSynthetic Biology Laboratory, Department of Structural and Functional Biology, Institute of Biology, UNICAMP, Campinas, SP Brazil.
Júlio César BorgesBiochemistry and Biophysics of Proteins Group-São Carlos Institute of Chemistry-IQSC, University of São Paulo, Trabalhador Sancarlense Avenue, 400, BQ1, S27, São Carlos, SP 13566-590, Brazil.ORCID 0000-0003-4856-748X
Fabio Trindade Maranhão-CostaLaboratory of Tropical Diseases-Prof. Dr. Luiz Jacinto da Silva, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas-UNICAMP, Campinas, SP 13083-970, Brazil.ORCID 0000-0001-9969-7300
Universidade Estadual de Campinas (UNICAMP) · BRFundação de Medicina Tropical · BRUniversidade de São Paulo · BRThe University of Melbourne · AUUniversidade Evangelica de Goiás · BRUniversity of Lisbon · PTUniversity of Gothenburg · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimalarial drugs with novel modes of action and wide therapeutic potential are needed to pave the way for malaria eradication. Violacein is a natural compound known for its biological activity against cancer cells and several pathogens, including the malaria parasite,

Indexed as

AntimalarialsIndolesMolecular ChaperonesPlasmodium falciparumAntimalarialsIndolesMolecular Chaperonesviolaceinchaperone inhibitorchemogenomicsmalariaproteostasisviolacein

Identifiers

PMID33689276
PMCPMC8042658
OpenAlexW3135154581

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.