Evidence map›Paper›PMID 33691476›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2021

Virtual Transcriptomics: Noninvasive Phenotyping of Atherosclerosis by Decoding Plaque Biology From Computed Tomography Angiography Imaging.

Andrew J Buckler, Eva Karlöf, Mariette Lengquist, T Christian Gasser, Lars Maegdefessel, Ljubica Perisic Matic, Ulf Hedin

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Artificial Intelligence in Coronary Artery Interventions: Preprocedural Planning and Procedural Assistance.Journal of the Society for Cardiovascular Angiography & Interventions · 2025
    Review
  8. Inflammation and resolution in obesity.Nature reviews. Endocrinology · 2025 · on this map
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Predicting Gene Expression From Computed Tomography Angiography.Arteriosclerosis, thrombosis, and vascular biology · 2021
    Article
  20. Explainable Machine-Learning Model to Classify Culprit Calcified Carotid Plaque in Embolic Stroke of Undetermined Source.Journal of neuroimaging : official journal of the American Society of Neuroimaging
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Andrew J BucklerDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden (A.J.B., E.K., M.L., L.P.M., U.H.).
Eva KarlöfDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden (A.J.B., E.K., M.L., L.P.M., U.H.).
Mariette LengquistDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden (A.J.B., E.K., M.L., L.P.M., U.H.).
T Christian GasserKTH Solid Mechanics, Department or Engineering Mechanics, KTH Royal Institute of Technology, Stockholm, Sweden (T.C.G.).
Lars MaegdefesselDepartment of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (L.M.).
Ljubica Perisic MaticDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden (A.J.B., E.K., M.L., L.P.M., U.H.).
Ulf HedinDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden (A.J.B., E.K., M.L., L.P.M., U.H.).
Karolinska Institutet · SEKTH Royal Institute of Technology · SE

Funding

vascuCAP: Non-invasive Computer-Aided Phenotyping of VasculopathyR44HL126224 · NHLBI · ELUCID · PI BUCKLER, ANDREW JOHN · 2015 to 2021
$4.6M
NHLBI NIH HHS R44 HL126224
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

Artificial IntelligenceComputed Tomography AngiographyCoronary AngiographyGene Expression ProfilingPlaque, AtheroscleroticRadiographic Image Interpretation, Computer-AssistedTranscriptomeAgedCoronary Artery DiseaseCoronary VesselsFeasibility StudiesFemaleHumansMaleModels, GeneticOligonucleotide Array Sequence Analysisangiographyatherosclerosiscardiovascular diseasephenotypestroke

Identifiers

PMID33691476
PMCPMC8062292
OpenAlexW3134808684

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.