Evidence map›Paper›PMID 33692120›Full record

GuidelineThe European respiratory journal2021

Management of hospitalised adults with coronavirus disease 2019 (COVID-19): a European Respiratory Society living guideline.

James D Chalmers, Megan L Crichton, Pieter C Goeminne, Bin Cao, Marc Humbert, Michal Shteinberg, Katerina M Antoniou, Charlotte Suppli Ulrik, Helen Parks, Chen Wang and 9 more

Erratum issuedOpen access · bronzeAbstract readPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in The European respiratory journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 121 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 9 pooled it
23.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 9 syntheses or guidelines pooled it, 228 citations in OpenAlex.

  1. Pooled it
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  3. Steroid therapy and antiviral treatment in SARS-CoV-2 pneumonia: clinical contexts and indications.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2022
    Pooled it
  4. Guideline
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  8. Guideline
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  10. Prolonged higher dose methylprednisoloneThe European respiratory journal · 2023
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  15. Article
  16. Observational
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61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 17 institutions in 11 countries.

James D ChalmersSchool of Medicine, University of Dundee, Dundee, UK jchalmers@dundee.ac.uk.ORCID https://orcid.org/0000-0001-5514-7868
Megan L CrichtonSchool of Medicine, University of Dundee, Dundee, UK.
Pieter C GoeminneDepartment of Respiratory Medicine, AZ Nikolaas, Sint-Niklaas, Belgium.
Bin CaoDepartment of Respiratory and Critical Care Medicine, Clinical Microbiology and Infectious Disease Lab, China-Japan Friendship Hospital, National Center for Respiratory Medicine, Institute of Respiratory Medicine, Chinese Academy of Medical Science, National Clinical Research Center of Respiratory Diseases, Beijing, China.
Marc HumbertService de Pneumologie et Soins Intensifs, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris (AP-HP); Université Paris-Saclay; Inserm UMR_S 999, Le Kremlin Bicêtre, France.ORCID https://orcid.org/0000-0003-0703-2892
Michal ShteinbergPulmonology institute and CF Center, Carmel Medical Center and the Technion-Israel Institute of Technology, Haifa, Israel.ORCID https://orcid.org/0000-0002-0432-3398
Katerina M AntoniouLaboratory of Molecular and Cellular Pneumonology, Department of Respiratory Medicine, School of Medicine, University of Crete, Heraklion, Greece.
Charlotte Suppli UlrikDepartment of Respiratory Medicine, Copenhagen University Hospital-Hvidovre Hospital, Hvidovre, Denmark.ORCID https://orcid.org/0000-0001-8689-3695
Helen ParksEuropean Lung Foundation, Sheffield, UK.
Chen WangDepartment of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center of Respiratory Diseases, Beijing, China.
Thomas VandendriesscheKU Leuven Libraries - 2Bergen - Learning Centre Désiré Collen, Leuven, Belgium.
Jieming QuDepartment of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai, China.
Daiana StolzClinic of Respiratory Medicine and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland.
Christopher BrightlingInstitute for Lung Health, Leicester NIHR BRC, University of Leicester, Leicester, UK.
Tobias WelteMedizinische Hochschule Hannover, Direktor der Abteilung Pneumologie, Hannover, Germany.ORCID https://orcid.org/0000-0002-9947-7356
Stefano AlibertiDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.ORCID https://orcid.org/0000-0002-0090-4531
Anita K SimondsSleep and Ventilation Unit, Royal Brompton and Harefield Hospital, Guys and St Thomas NHS Foundation Trust, London, UK.
Thomy ToniaInstitute of Social and Preventive Medicine, University Bern, Bern, Switzerland.
Nicolas RocheRespiratory Medicine, Cochin Hospital, APHP Centre-University of Paris, Cochin Institute (INSERM UMR1016), Paris, France.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNRoche (Switzerland) · CHBritish Lung Foundation · GBGuy's and St Thomas' NHS Foundation Trust · GBHumanitas University · ITInserm · FRMedizinische Hochschule Hannover · DEShanghai Jiao Tong University · CNTechnion – Israel Institute of Technology · ILUniversity Colleges Leuven-Limburg · BEUniversity of Bern · CHUniversity of Copenhagen · DKUniversity of Crete · GRUniversity of Dundee · GBUniversity of Freiburg · DEUniversity of Leicester · GBVlaamse Vereniging voor Obstetrie en Gynaecolo · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHospitalised patients with coronavirus disease 2019 (COVID-19) as a result of SARS-CoV-2 infection have a high mortality rate and frequently require noninvasive respiratory support or invasive ventilation. Optimising and standardising management through evidence-based guidelines may improve quality of care and therefore patient outcomes.

methodsA task force from the European Respiratory Society and endorsed by the Chinese Thoracic Society identified priority interventions (pharmacological and non-pharmacological) for the initial version of this "living guideline" using the PICO (population, intervention, comparator, outcome) format. The GRADE approach was used for assessing the quality of evidence and strength of recommendations. Systematic literature reviews were performed, and data pooled by meta-analysis where possible. Evidence tables were presented and evidence to decision frameworks were used to formulate recommendations.

resultsBased on the available evidence at the time of guideline development (20 February, 2021), the panel makes a strong recommendation in favour of the use of systemic corticosteroids in patients requiring supplementary oxygen or ventilatory support, and for the use of anticoagulation in hospitalised patients. The panel makes a conditional recommendation for interleukin (IL)-6 receptor antagonist monoclonal antibody treatment and high-flow nasal oxygen or continuous positive airway pressure in patients with hypoxaemic respiratory failure. The panel make strong recommendations against the use of hydroxychloroquine and lopinavir-ritonavir. Conditional recommendations are made against the use of azithromycin, hydroxychloroquine combined with azithromycin, colchicine, and remdesivir, in the latter case specifically in patients requiring invasive mechanical ventilation. No recommendation was made for remdesivir in patients requiring supplemental oxygen. Further recommendations for research are made.

conclusionThe evidence base for management of COVID-19 now supports strong recommendations in favour and against specific interventions. These guidelines will be regularly updated as further evidence becomes available.

Indexed as

HospitalizationAdrenal Cortex HormonesAdultCOVID-19HumansMeta-Analysis as TopicRespiration, ArtificialSystematic Reviews as TopicAdrenal Cortex Hormones

Identifiers

PMID33692120
PMCPMC7947358
OpenAlexW3133932534

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.