ArticleScience translational medicine2021
Long-lasting analgesia via targeted in situ repression of Na
Open access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed
9.7field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
80 citing papers in PubMed, 114 citations in OpenAlex.
- Targeting Spinal Dorsal Horn Sensitisation in Chronic Pain: Mechanisms and Translational Strategies.Neuroscience bulletin · 2026Review
- Initial efforts of translational development of AAV-encoded NaMolecular therapy. Advances · 2026Article
- ERAD-level gene switches for on-demand protein secretion and rapidly controlled gene therapies.Nature communications · 2026Article
- Recombinant dimeric PICK1 peptide inhibitors for long-term relief of chronic pain by AAV therapeutics.Cell reports. Medicine · 2026Article
- Structural basis for inhibition of the voltage-gated sodium channel NaThe Journal of biological chemistry · 2026Article
- Recent advances in nanomaterial-based strategies for chronic pain alleviation.Materials today. Bio · 2026Review
- Review
- Efficient genetic perturbation of murine sensory neurons in vivo using CRISPR/Cas9.The journal of pain · 2026Article
- Activation of GPR35 in the Anterior Cingulate Cortex Alleviates Neuropathic Pain and Depression-Related Behavior.CNS neuroscience & therapeutics · 2026Article
- Sodium Channel Inhibitors in Clinical Development for Pain Management: A Focused Review.CNS drugs · 2026Review
- Epigenome editing based treatment: Progresses and challenges.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Review
- Review of Physiology, Pathology, and Pharmacology of Voltage-Gated Sodium Channels in Regards to the Potential Role of NaV 1.8 Selective Inhibitor, Suzetrigine, for Chronic Pain Management.Journal of pain research · 2026Review
- Precision acupuncture for chemotherapy-induced peripheral neuropathy: multitarget mechanisms and integrated clinical translation framework.Frontiers in neurology · 2026Review
- Recent advances in the pharmacology of voltage-gated ion channels.Pharmacological reviews · 2025Review
- Neuronal Endothelin a Receptor Mediates Experimental and Clinical Vascular Pain through an Endothelial-Neural Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Rewriting the vascular script: epigenetic modifiers as scribes of metabolic reprogramming in pulmonary hypertension.Journal of molecular medicine (Berlin, Germany) · 2025Review
- Efficient genetic perturbation of murine sensory neuronsbioRxiv : the preprint server for biology · 2025Article
- Review
- Targeting sodium channels - challenges for acute pain and the leap to chronic pain.Nature reviews. Neurology · 2025Review
- Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain.Cell · 2025Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
19 authors at 3 institutions in 1 country.
Ana M MorenoDepartment of Bioengineering, University of California San Diego, San Diego, CA 92093, USA.ORCID 0000-0002-5290-551X
Fernando AlemánDepartment of Bioengineering, University of California San Diego, San Diego, CA 92093, USA.ORCID 0000-0003-0327-1343
Glaucilene F CatroliDepartment of Anesthesiology, University of California San Diego, San Diego, CA 92093, USA.ORCID 0000-0002-9026-176X
Matthew HuntDepartment of Anesthesiology, University of California San Diego, San Diego, CA 92093, USA.ORCID 0000-0001-6800-8592
Michael HuDepartment of Bioengineering, University of California San Diego, San Diego, CA 92093, USA.ORCID 0000-0002-7321-9199
Amir DailamyDepartment of Bioengineering, University of California San Diego, San Diego, CA 92093, USA.ORCID 0000-0002-6711-8260
Andrew PlaDepartment of Bioengineering, University of California San Diego, San Diego, CA 92093, USA.
Sarah A WollerDepartment of Anesthesiology, University of California San Diego, San Diego, CA 92093, USA.ORCID 0000-0001-7767-4845
Nathan PalmerDivision of Biological Sciences, University of California San Diego , San Diego, CA 92093, USA.ORCID 0000-0001-6347-9379
Udit ParekhDepartment of Electrical Engineering, University of California San Diego , San Diego, CA 92093, USA.ORCID 0000-0002-6395-1781
Daniella McDonaldDepartment of Bioengineering, University of California San Diego, San Diego, CA 92093, USA.
Amanda J RobertsAnimal Models Core, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-4044-8884
Vanessa GoodwillDepartment of Neuropathology, University of California San Diego, San Diego, CA 92093, USA.
Ian DrydenDepartment of Neuropathology, University of California San Diego, San Diego, CA 92093, USA.ORCID 0000-0002-8590-2681
Robert F HevnerDepartment of Neuropathology, University of California San Diego, San Diego, CA 92093, USA.ORCID 0000-0002-8441-1047
Lauriane DelayDepartment of Anesthesiology, University of California San Diego, San Diego, CA 92093, USA.ORCID 0000-0002-5466-9856
Gilson Gonçalves Dos SantosDepartment of Anesthesiology, University of California San Diego, San Diego, CA 92093, USA.ORCID 0000-0002-2704-3006
Tony L YakshDepartment of Anesthesiology, University of California San Diego, San Diego, CA 92093, USA. pmali@ucsd.edu tyaksh@ucsd.edu.ORCID 0000-0003-4297-536X
Prashant MaliDepartment of Bioengineering, University of California San Diego, San Diego, CA 92093, USA. pmali@ucsd.edu tyaksh@ucsd.edu.ORCID 0000-0002-3383-1287
University of California San Diego · USUniversity of San Diego · USScripps Research Institute · US
Funding
U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0MPreclinical optimization of a gene therapy for erythromelalgia and chronic painU44NS122114 · NINDS · NAVEGA THERAPEUTICS, INC. · PI ALEMAN GUILLEN, FERNANDO, MORENO, ANA MARIA · 2021 to 2024
$4.3MNext-generation Functional Genetic Screening of Un-screenable TraitsR01HG009285 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALI, PRASHANT, TAMAYO, PABLO · 2017 to 2020
$4.2MRheumatic Diseases Research Training GrantT32AR064194 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GARY S FIRESTEIN, Monica Guma · 2013 to 2026
$3.8MAIBP and regulation of neuropathic painR01NS102432 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILLER, YURY, YAKSH, TONY L. · 2017 to 2021
$3.0MTreatment of Chemotherapy-Induced Peripheral Neuropathy via Genetic Repression of Sodium ChannelsR44CA239940 · NCI · NAVEGA THERAPEUTICS, INC. · PI ALEMAN GUILLEN, FERNANDO, MORENO, ANA MARIA · 2021 to 2022
$2.2MSystematic mapping of genetic vulnerabilities in head and neck cancerR01CA222826 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALI, PRASHANT · 2018 to 2022
$1.8MSex, Stress and Immunity in the Acute to Chronic Pain TransitionR01NS099338 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YAKSH, TONY L. · 2017 to 2021
$1.8MDissecting the interplay of gene regulatory networks and cellular niche on cell fate determinationR01GM123313 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALI, PRASHANT · 2018 to 2021
$1.2MSupplement to Promote Diversity and Inclusion, Female ScientistR43NS112088 · NINDS · NAVEGA THERAPEUTICS, INC. · PI ALEMAN GUILLEN, FERNANDO, MORENO, ANA MARIA · 2019 to 2020
$624kIllumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600kTreatment of Chemotherapy-Induced Peripheral Neuropathy via Genetic Repression of Sodium ChannelsR43CA239940 · NCI · NAVEGA THERAPEUTICS, INC. · PI ALEMAN GUILLEN, FERNANDO, MORENO, ANA MARIA · 2019 to 2019
$288kNCI NIH HHS R01 CA222826NCI NIH HHS R43 CA239940NCI NIH HHS R44 CA239940NHGRI NIH HHS R01 HG009285NIAMS NIH HHS T32 AR064194NIGMS NIH HHS R01 GM123313NIH HHS S10 OD026929NINDS NIH HHS P30 NS047101NINDS NIH HHS R01 NS099338NINDS NIH HHS R01 NS102432NINDS NIH HHS R43 NS112088
Abstract
Current treatments for chronic pain rely largely on opioids despite their substantial side effects and risk of addiction. Genetic studies have identified in humans key targets pivotal to nociceptive processing. In particular, a hereditary loss-of-function mutation in Na
Indexed as
AnalgesiaChronic PainNeuralgiaAnimalsGanglia, SpinalHyperalgesiaMice
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What Socratic holds
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.