Evidence map›Paper›PMID 33694155›Full record

ArticleBritish journal of pharmacology2021

Halofuginone, a promising drug for treatment of pulmonary hypertension.

Pritesh P Jain, Tengteng Zhao, Mingmei Xiong, Shanshan Song, Ning Lai, Qiuyu Zheng, Jiyuan Chen, Shane G Carr, Aleksandra Babicheva, Amin Izadi and 11 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Store-operated CaAmerican journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Mechanosensitive channel Piezo1 is required for pulmonary artery smooth muscle cell proliferation.American journal of physiology. Lung cellular and molecular physiology · 2022
    Article
  14. Mechanisms of pulmonary vascular dysfunction in pulmonary hypertension and implications for novel therapies.American journal of physiology. Heart and circulatory physiology · 2022
    Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. TRPC6, a therapeutic target for pulmonary hypertension.American journal of physiology. Lung cellular and molecular physiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 2 institutions in 2 countries.

Pritesh P JainSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California, USA.
Tengteng ZhaoSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California, USA.
Mingmei XiongSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California, USA.
Shanshan Song
Ning LaiSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California, USA.
Qiuyu ZhengDivision of Endocrinology and Metabolism, University of California, San Diego, La Jolla, California, USA.
Jiyuan ChenSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California, USA.
Shane G Carr
Aleksandra BabichevaSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California, USA.
Amin IzadiSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California, USA.
Marisela RodriguezSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California, USA.
Shamin RahimiSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California, USA.
Francesca BalistrieriSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California, USA.
Shayan RahimiSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California, USA.
Tatum SimonsonSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California, USA.
Daniela Valdez-JassoDepartment of Bioengineering, University of California, San Diego, La Jolla, California, USA.
Patricia A ThistlethwaiteDivision of Cardiothoracic Surgery, Department of Surgery, University of California, San Diego, La Jolla, California, USA.
John Y-J ShyyDivision of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla, California, USA.
Jian WangSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California, USA.
Ayako MakinoDivision of Endocrinology and Metabolism, University of California, San Diego, La Jolla, California, USA.ORCID 0000-0003-1259-8604
Jason X-J YuanSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California, USA.
University of California System · USUniversity of California San Diego · US

Funding

Ion Channels and Membrane Receptors in Pulmonary Arterial HypertensionR35HL135807 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YUAN, JASON X J · 2017 to 2023
$5.6M
Coronary Endothelial Cell Dysfunction in Diabetes: Role of MFGE8R01HL142214 · NHLBI · UNIVERSITY OF FLORIDA · PI Yun Sok Lee, Ayako Makino · 2018 to 2026
$3.2M
Molecular Mechanisms of Pulmonary HypertensionR01HL070852 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI THISTLETHWAITE, PATRICIA A · 2002 to 2011
$3.1M
Multiscale Modeling of Right Ventricular Fibrotic Remodeling in Pulmonary Arterial HypertensionR01HL155945 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI VALDEZ-JASSO, DANIELA · 2021 to 2025
$1.9M
Role of Gap Junction in Hypoxia-induced Pulmonary HypertensionR01HL146764 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MAKINO, AYAKO · 2019 to 2022
$1.6M
NHLBI NIH HHS R01 HL070852NHLBI NIH HHS R01 HL142214NHLBI NIH HHS R01 HL146764NHLBI NIH HHS R01 HL155945NHLBI NIH HHS R35 HL135807NIH HHS R01 HL142214NIH HHS R01 HL146764NIH HHS R35 HL135807
6 · The paper itself

Abstract

background and purposeHalofuginone is a febrifugine derivative originally isolated from Chinese traditional herb Chang Shan that exhibits anti-hypertrophic, anti-fibrotic and anti-proliferative effects. We sought to investigate whether halofuginone induced pulmonary vasodilation and attenuates chronic hypoxia-induced pulmonary hypertension (HPH). EXPERIMENTAL APPROACH: Patch-clamp experiments were conducted to examine the activity of voltage-dependent Ca KEY

resultsHalofuginone increased voltage-gated K CONCLUSION AND IMPLICATIONS: Halofuginone is a potent pulmonary vasodilator by activating K

Indexed as

Hypertension, PulmonaryPharmaceutical PreparationsAnimalsCalciumHypoxiaMiceMyocytes, Smooth MusclePhosphatidylinositol 3-KinasesPiperidinesPulmonary ArteryQuinazolinonesCalciumhalofuginonePharmaceutical PreparationsPhosphatidylinositol 3-KinasesPiperidinesQuinazolinonesCa2+ channelhalofuginoneK+ channelKCNA5Pulmonary arterial hypertensionsmooth muscle celltreatment

Identifiers

PMID33694155
PMCPMC9792225
OpenAlexW3135899205

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.