ArticleJournal of applied physiology (Bethesda, Md. : 1985)2021
Effects of age and sex on middle cerebral artery blood velocity and flow pulsatility index across the adult lifespan.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
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- Epidemiology and Risk Factors of Mycotic Aneurysm in Patients With Infective Endocarditis and the Impact of its Rupture in Outcomes. Analysis of a National Prospective Cohort.Open forum infectious diseases · 2024Trial
- Cerebrovascular pulsatility following long duration spaceflight is associated with changes in pulse pressure and carotid artery stiffness.Experimental physiology · 2026Article
- Sex comparison of cerebrovascular reactivity to COJournal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Intracranial vasomotor and blood flow responses to light-intensity aerobic exercise in young adults: a 4D flow MRI study.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Pulsatility Index Measurement via the Submandibular Internal Carotid Artery: An Alternative to Transcranial Assessment.Neurocritical care · 2026Article
- Sex differences in cerebrovascular function across an aerobic exercise intervention in older adults using MRI: Results from the Brain in Motion study.Physiological reports · 2026Article
- Sex differences in dynamic cerebral autoregulation responses to resistance and endurance training in humans.Experimental physiology · 2026Article
- Longitudinal sex differences in cerebrovascular ageing in older adults: results from the brain in motion study.The Journal of physiology · 2026Article
- Sex differences in cerebral pulsatility and damping: A 4D flow MRI study.Experimental physiology · 2026Article
- Intracranial arterial calcification and cerebrovascular function in the general aging population - A 7T MRI Study.Cerebral circulation - cognition and behavior · 2026Article
- Age-related variations of the hemodynamic response function spatially resolved across human cerebral cortex.Frontiers in aging neuroscience · 2026Article
- Cerebral and cervical hemodynamic differences in adolescents with first-episode depressive disorder: a TCCD and cervical artery ultrasound study.Frontiers in psychiatry · 2026Article
- The impact of age and sex on cerebral and large artery stiffness and the response to pulse pressure.American journal of physiology. Heart and circulatory physiology · 2025Article
- Age alters integrated cerebrovascular and cardiovascular dynamic responses to exercise: insights from a systems modeling approach.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Assessing cerebral microvascular pulsatility using flow pulsatile-resolved pseudo-continuous arterial spin labeling MRI.Magnetic resonance in medicine · 2025Article
- Cerebral haemodynamic responses to inspiratory muscle work.Experimental physiology · 2025Article
- Simultaneous Assessment of Arterial Pulsatility Across Multiple Segments of Cerebral Arteries Using Multiband Dual-VENC Phase-Contrast MRI.NMR in biomedicine · 2025Article
- Article
- Estrogen Enhances SK Channel Activity to Limit Hippocampal Arteriole Constriction.Circulation research · 2025Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Reduced middle cerebral artery blood velocity (MCAv) and flow pulsatility are contributors to age-related cerebrovascular disease pathogenesis. It is unknown whether the rate of changes in MCAv and flow pulsatility support the hypothesis of sex-specific trajectories with aging. Therefore, we sought to characterize the rate of changes in MCAv and flow pulsatility across the adult lifespan in females and males as well as within specified age ranges. Participant characteristics, mean arterial pressure, end-tidal carbon dioxide, unilateral MCAv, and flow pulsatility index (PI) were determined from study records compiled from three institutional sites. A total of 524 participants [18-90 yr; females 57 (17) yr,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.