Evidence map›Paper›PMID 33705657›Full record

ArticleJournal of the American Chemical Society2021

Total Synthesis and Target Identification of the Curcusone Diterpenes.

Chengsen Cui, Brendan G Dwyer, Chang Liu, Daniel Abegg, Zhong-Jian Cai, Dominic G Hoch, Xianglin Yin, Nan Qiu, Jie-Qing Liu, Alexander Adibekian and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 53 citations in OpenAlex.

  1. Total Synthesis of (±)-Stemocurtisine via Catalytic Carbonylation.Journal of the American Chemical Society · 2026
    Article
  2. Article
  3. Evolution of a Synthetic Strategy for Complex Diterpenes fromJournal of the American Chemical Society · 2026
    Article
  4. Total Synthesis of (-)-Psathyrin A Enabled by Radical Cyclization.Journal of the American Chemical Society · 2025
    Article
  5. Review
  6. Article
  7. Chemoproteomics-EnabledJournal of the American Chemical Society · 2025
    Article
  8. Review
  9. BRAT1 - a new therapeutic target for glioblastoma.Cellular and molecular life sciences : CMLS · 2025
    Article
  10. Article
  11. Article
  12. Pharmaceuticals (Basel, Switzerland) · 2024
    Review
  13. Concise Total Syntheses of (Journal of the American Chemical Society · 2024
    Article
  14. Neuronal differentiation requires BRAT1 complex to remove REST from chromatin.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Chengsen CuiDepartment of Chemistry and Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, United States.ORCID 0000-0002-6867-1826
Brendan G DwyerDepartment of Chemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, Florida 33458, United States.
Chang LiuDepartment of Chemistry and Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, United States.
Daniel AbeggDepartment of Chemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, Florida 33458, United States.
Zhong-Jian CaiDepartment of Chemistry and Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, United States.
Dominic G HochDepartment of Chemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, Florida 33458, United States.
Xianglin YinDepartment of Chemistry and Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, United States.
Nan QiuDepartment of Chemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, Florida 33458, United States.
Jie-Qing LiuSchool of Medicine, Huaqiao University, Quanzhou 362021, P. R. China.
Alexander AdibekianDepartment of Chemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, Florida 33458, United States.ORCID 0000-0001-6453-0244
Mingji DaiDepartment of Chemistry and Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, United States.ORCID 0000-0001-7956-6426
Purdue University West Lafayette · USScripps Research Institute · USHuaqiao University · CN

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI ANDREW D MESECAR · 1985 to 2026
$43.4M
Synthesis and Study of Medicinally Important MoleculesR35GM128570 · NIGMS · PURDUE UNIVERSITY · PI Mingji Dai · 2018 to 2026
$3.7M
NCI NIH HHS P30 CA023168NIGMS NIH HHS R35 GM128570
6 · The paper itself

Abstract

The curcusone natural products are complex diterpenes featuring a characteristic [6-7-5] tricyclic carbon skeleton similar to the

Indexed as

Biological ProductsDiterpenesHumansMolecular ConformationNuclear ProteinsStereoisomerismBiological ProductsBRAT1 protein, humancurcusone Bcurcusone DDiterpenesNuclear Proteins

Identifiers

PMID33705657
PMCPMC8281983
OpenAlexW3134628463

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.