Evidence map›Paper›PMID 33706717›Full record

ArticleBMC medical research methodology2021

Population segmentation of type 2 diabetes mellitus patients and its clinical applications - a scoping review.

Jun Jie Benjamin Seng, Amelia Yuting Monteiro, Yu Heng Kwan, Sueziani Binte Zainudin, Chuen Seng Tan, Julian Thumboo, Lian Leng Low

Abstract readScoping Review
In one paragraph

Article in BMC medical research methodology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jun Jie Benjamin SengDuke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore.ORCID 0000-0002-3039-3816
Amelia Yuting MonteiroDuke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore.ORCID 0000-0001-8764-9627
Yu Heng KwanSingHealth Regional Health System PULSES Centre, Singapore Health Services, Outram Rd, Singapore, 169608, Singapore.ORCID 0000-0001-7802-9696
Sueziani Binte ZainudinDepartment of General Medicine (Endocrinology), Sengkang General Hospital, Singapore, Singapore.ORCID 0000-0003-1686-0358
Chuen Seng TanSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Republic of Singapore.ORCID 0000-0002-6513-2309
Julian ThumbooSingHealth Regional Health System PULSES Centre, Singapore Health Services, Outram Rd, Singapore, 169608, Singapore.ORCID 0000-0001-6712-5535
Lian Leng LowSingHealth Regional Health System PULSES Centre, Singapore Health Services, Outram Rd, Singapore, 169608, Singapore. low.lian.leng@singhealth.com.sg.ORCID 0000-0003-4228-2862

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPopulation segmentation permits the division of a heterogeneous population into relatively homogenous subgroups. This scoping review aims to summarize the clinical applications of data driven and expert driven population segmentation among Type 2 diabetes mellitus (T2DM) patients.

methodsThe literature search was conducted in Medline®, Embase®, Scopus® and PsycInfo®. Articles which utilized expert-based or data-driven population segmentation methodologies for evaluation of outcomes among T2DM patients were included. Population segmentation variables were grouped into five domains (socio-demographic, diabetes related, non-diabetes medical related, psychiatric / psychological and health system related variables). A framework for PopulAtion Segmentation Study design for T2DM patients (PASS-T2DM) was proposed.

resultsOf 155,124 articles screened, 148 articles were included. Expert driven population segmentation approach was most commonly used, of which judgemental splitting was the main strategy employed (n = 111, 75.0%). Cluster based analyses (n = 37, 25.0%) was the main data driven population segmentation strategies utilized. Socio-demographic (n = 66, 44.6%), diabetes related (n = 54, 36.5%) and non-diabetes medical related (n = 18, 12.2%) were the most used domains. Specifically, patients' race, age, Hba1c related parameters and depression / anxiety related variables were most frequently used. Health grouping/profiling (n = 71, 48%), assessment of diabetes related complications (n = 57, 38.5%) and non-diabetes metabolic derangements (n = 42, 28.4%) were the most frequent population segmentation objectives of the studies.

conclusionsPopulation segmentation has a wide range of clinical applications for evaluating clinical outcomes among T2DM patients. More studies are required to identify the optimal set of population segmentation framework for T2DM patients.

Indexed as

Diabetes Mellitus, Type 2HumansCluster analysisData analysisDiabetes mellitus, type 2Latent class analysisOutcome assessment, health carePatient outcome assessmentPopulation segmentationScoping review

Identifiers

PMID33706717
PMCPMC7953703

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.