Evidence map›Paper›PMID 33708176›Full record

ArticleFrontiers in endocrinology2021

Absence of Thyroid Hormone Induced Delayed Dendritic Arborization in Mouse Primary Hippocampal Neurons Through Insufficient Expression of Brain-Derived Neurotrophic Factor.

Hiroyuki Yajima, Izuki Amano, Sumiyasu Ishii, Tetsushi Sadakata, Wataru Miyazaki, Yusuke Takatsuru, Noriyuki Koibuchi

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Serum Neudesin Levels in Patients with Congenital HypothyroidismJournal of clinical research in pediatric endocrinology · 2025
    Article
  4. Review
  5. Article
  6. Review
  7. Primary Hypothyroidism and Alzheimer's Disease: A Tale of Two.Cellular and molecular neurobiology · 2023
    Review
  8. Local Thyroid Hormone Action in Brain Development.International journal of molecular sciences · 2023
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Hiroyuki YajimaDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Izuki AmanoDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Sumiyasu IshiiDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Tetsushi SadakataEducation and Research Support Center, Gunma University Graduate School of Medicine, Maebashi, Japan.
Wataru MiyazakiDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Yusuke TakatsuruDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Noriyuki KoibuchiDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Gunma University · JPHirosaki University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thyroid hormone (TH) plays important roles in the developing brain. TH deficiency in early life leads to severe developmental impairment in the hippocampus. However, the mechanisms of TH action in the developing hippocampus are still largely unknown. In this study, we generated 3,5,3'-tri-iodo-l-thyronine (T

Indexed as

AnimalsBrain-Derived Neurotrophic FactorCell ProliferationCells, CulturedCell SurvivalDendritesFemaleGene Expression RegulationHippocampusMiceMice, Inbred C57BLNeuronsPhosphorylationPresynaptic TerminalsReceptor, trkBRNA, MessengerBrain-Derived Neurotrophic FactorReceptor, trkBRNA, MessengerThyroid Hormonesbrain-derived neurotrophic factordendrite growthhippocampushypothyroidismprimary cultureSholl analysis

Identifiers

PMID33708176
PMCPMC7940752
OpenAlexW3129730626

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.