ArticleAnnals of translational medicine2021
Heart rate fluctuation predicts mortality in critically ill patients in the intensive care unit: a retrospective cohort study.
Article in Annals of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Early heart-rate trajectory phenotypes predict short-term mortality in critically ill patients: a dynamic time-warping cluster analysis.Journal of clinical monitoring and computing · 2026Article
- Observational
- Association between heart rate fluctuation and mortality in intensive care patients with atrial fibrillation.Scientific reports · 2025Article
- Design and Development of a Machine Learning Model for Predicting ICU Patients' Length of Stay.Cureus · 2025Article
- Use of portable single-lead electrocardiogram device as an alternative for QTc monitoring in critically ill patients.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2024Article
- Identifying vital sign trajectories to predict 28-day mortality of critically ill elderly patients with acute respiratory distress syndrome.Respiratory research · 2024Article
- The search for optimal nocturnal diurnal heart rate Index targets in ICU patients: a retrospective observational study from large ICU database.Frontiers in cardiovascular medicine · 2024Article
- Article
- Clinical surrogates of dysautonomia predict lethal outcome in COVID-19 on intensive care unit.Neurological research and practice · 2023Article
- Bradycardia and Heart Rate Fluctuation Are Associated with a Prolonged Intensive Care Unit Stay in Patients with Severe COVID-19.Medicina (Kaunas, Lithuania) · 2022Article
- Heart Rate Fluctuation and Mortality in Critically Ill Myocardial Infarction Patients: A Retrospective Cohort Study.Frontiers in cardiovascular medicine · 2021Article
- Admission Resting Heart Rate as an Independent Predictor of All-Cause Mortality in Elderly Patients with Hip Fracture.International journal of general medicine · 2021Article
- Exploring the feasibility of vital signs-based mortality risk prediction in a care facility setting.Digital healthArticle
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo evaluate the association between heart rate (HR) fluctuation and mortality in critically ill patients in the intensive care unit (ICU).
methodsA total of 27,814 patients were enrolled from the Medical Information Mart for Intensive Care database and were divided into 3 groups: low HR fluctuation [<25 beats per minute (bpm)], control (25-34 bpm), and high HR fluctuation (≥35 bpm), based on the initial 24-hour HR fluctuation (calculated as the maximum HR minus minimum HR). Multivariate Cox regression and restricted cubic spline models were used.
resultsCompared to the control group, higher risk of 28-day and 1-year mortality remained significant in an adjusted model, with hazard ratios of 1.210 [95% confidence interval (CI), 1.103-1.327] and 1.150 (95% CI, 1.078-1.227), respectively, in the high HR fluctuation group, as well as hazard ratios of 1.130 (95% CI, 1.035-1.232) and 1.087 (95% CI, 1.022-1.157), respectively, in the low HR fluctuation group. Restricted cubic splines showed a U-type curve, with the lowest risk of mortality at an HR fluctuation of 30 bpm.
conclusionsThis retrospective cohort study revealed that both high and low HR fluctuation correlated with increased mortality in critically ill ICU patients, providing new insights for optimizing HR control strategies.
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