ReviewNeuropharmacology2021
Neurobiological mechanisms of early life adversity, blunted stress reactivity and risk for addiction.
Review in Neuropharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Physiological responses to acute psychological stress as a biomarker for depression: A systematic review and meta-analysis.Psychological bulletinPooled it
- Adverse Childhood Experiences and Substance Use: The Mediating Role of Executive Function Deficits.Journal of adolescence · 2026Article
- Development of the Yale pain stress test to elicit a multi-level stress response and assess stress adaptability.Psychopharmacology · 2026Article
- Predicting externalizing symptom trajectories in U.S. National Guard recruits: The role of adverse childhood experiences.Journal of traumatic stress · 2026Article
- Recalibrating stress regulation through mindfulness: a framework for adapting interventions for ACE-affected populations.Frontiers in psychology · 2026Article
- Assessing Autonomic Regulation Under Stress with the Yale Pain Stress Test in Social Drinking and Alcohol Use Disorder.Behavioral sciences (Basel, Switzerland) · 2025Article
- The impact of childhood maltreatment and parental styles on telomere length: the modulatory role of A118G.European journal of psychotraumatology · 2025Article
- Parental Adverse Childhood Experiences and Adolescents' Depressive Symptoms: Roles of Parenting Stress and Parent-child Attachment.Research on child and adolescent psychopathology · 2025Article
- Adverse childhood experiences as predictors of alcohol and tobacco addiction risk among college students in Delhi-NCR, India.Scientific reports · 2025Article
- Stress across systems and lifespan: emerging biomarkers and mechanisms of resilience.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Early life adversity increases risk for chronic post-traumatic pain, data from humans and rodents.Pain · 2025Article
- Associations of childhood adversity and substance use disorder polygenic scores with disorder severity and diagnostic criteria.Psychological medicine · 2025Article
- Impact of Early-Life Adversity on Cannabis Use: Exploring the Mediating and Moderating Effects of Chronic Pain.Cannabis and cannabinoid research · 2025Article
- Retrotransposons and the brain: Exploring a complex relationship between mobile elements, stress, and neurological health.Neurobiology of stress · 2025Review
- Nicotine addiction and the influence of life adversity and acute stress on PYY: Prediction of early smoking relapse.Pharmacology research & perspectives · 2024Article
- Stress and substance use disorders: risk, relapse, and treatment outcomes.The Journal of clinical investigation · 2024Review
- Early resource scarcity causes cortical astrocyte enlargement and sex-specific changes in the orbitofrontal cortex transcriptome in adult rats.Neurobiology of stress · 2024Article
- Psychological risk factors and cardiovascular disease.Frontiers in psychology · 2024Review
- Childhood adversity predicts striatal functional connectivity gradient changes after acute stress.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Early life adversity and substance use: The mediating role of mood and the moderating role of impulsivity.Journal of psychiatric research · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Blunted stress reactivity resulting from early exposure to stress during childhood and adolescence may increase vulnerability to addiction. Early life adversity (ELA) affects brain structure and function and results in blunted stress axis reactivity. In this review, we focus on the underlying neurobiological mechanisms associated with a blunted response to stress, ELA, and risk for addictive disorders. ELA and blunted reactivity are accompanied by unstable mood regulation, impulsive behaviors, and reduced cognitive function. Neuroimaging studies reveal cortical and subcortical changes in persons exposed to ELA and those who have a genetic disposition for addiction. We propose a model in which blunted stress reactivity may be a marker of risk for addiction through an altered motivational and behavioral reactivity to stress that contribute to disinhibited behavioral reactivity and impulsivity leading in turn to increased vulnerability for substance use. Evidence supporting this hypothesis in the context of substance use initiation, maintenance, and risk for relapse is presented. The effects of ELA on persons at risk for addiction may lead to early experimentation with drugs of abuse. Early adoption of drug intake may alter neuroregulation in such vulnerable persons leading to a permanent dysregulation of motivational responses consistent with dependence. This article is part of the special issue on 'Vulnerabilities to Substance Abuse'.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.