Evidence map›Paper›PMID 33716987›Full record

ArticleFrontiers in endocrinology2021

Nerve Growth Factor: A Dual Activator of Noradrenergic and Cholinergic Systems of the Rat Ovary.

Agustin Benitez, Raul Riquelme, Miguel Del Campo, Camila Araya, Hernan E Lara

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Agustin BenitezCentre for Neurobiochemical Studies in Neuroendocrine Diseases, Laboratory of Neurobiochemistry, Faculty of Chemistry and Pharmaceutical Sciences, Universidad de Chile, Independencia, Chile.
Raul RiquelmeCentre for Neurobiochemical Studies in Neuroendocrine Diseases, Laboratory of Neurobiochemistry, Faculty of Chemistry and Pharmaceutical Sciences, Universidad de Chile, Independencia, Chile.
Miguel Del CampoCentre for Neurobiochemical Studies in Neuroendocrine Diseases, Laboratory of Neurobiochemistry, Faculty of Chemistry and Pharmaceutical Sciences, Universidad de Chile, Independencia, Chile.
Camila ArayaCentre for Neurobiochemical Studies in Neuroendocrine Diseases, Laboratory of Neurobiochemistry, Faculty of Chemistry and Pharmaceutical Sciences, Universidad de Chile, Independencia, Chile.
Hernan E LaraCentre for Neurobiochemical Studies in Neuroendocrine Diseases, Laboratory of Neurobiochemistry, Faculty of Chemistry and Pharmaceutical Sciences, Universidad de Chile, Independencia, Chile.
University of Chile · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The functioning of the ovary is influenced by the autonomic system (sympathetic and cholinergic intraovarian system) which contributes to the regulation of steroid secretion, follicular development, and ovulation. There is no information on the primary signal that activates both systems. The nerve growth factor (NGF) was the first neurotrophic factor found to regulate ovarian noradrenergic neurons and the cholinergic neurons in the central nervous system. The aim of this study was to determine whether NGF is one of the participating neurotrophic factors in the activation of the sympathetic and cholinergic system of the ovary

Indexed as

AcetylcholineAcetylcholinesteraseAnimalsAutonomic Nervous SystemCarbacholCholine O-AcetyltransferaseEstradiolEstrusFemaleNerve Growth FactorNorepinephrineOsmosisOvaryOvulationPhenotypePolycystic Ovary SyndromeAcetylcholineAcetylcholinesteraseCarbacholCholine O-AcetyltransferaseEstradiolNerve Growth FactorNgf protein, ratNorepinephrineProtein IsoformsReceptors, AdrenergicReceptors, CholinergicSteroidsacetylcholinefollicular developmentnerve growth factornorepinephrinepolycystic ovary syndrome

Identifiers

PMID33716987
PMCPMC7947612
OpenAlexW3130019910

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.