Evidence map›Paper›PMID 33719496›Full record

SynthesisJournal of the American Heart Association2021

Effects of Influenza Vaccine on Mortality and Cardiovascular Outcomes in Patients With Cardiovascular Disease: A Systematic Review and Meta-Analysis.

Siva H Yedlapati, Safi U Khan, Swapna Talluri, Ahmed N Lone, Muhammad Zia Khan, Muhammad Shahzeb Khan, Ann M Navar, Martha Gulati, Heather Johnson, Seth Baum and 1 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 9 pooled it
19.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 9 syntheses or guidelines pooled it, 163 citations in OpenAlex.

  1. Guideline
  2. Pooled it
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  10. Trial
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  13. Review
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33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 2 countries.

Siva H YedlapatiDepartment of Medicine Erie County Medical Center Buffalo NY.
Safi U KhanDepartment of Medicine West Virginia University Morgantown WV.
Swapna TalluriDepartment of Medicine Guthrie Health System/Robert Packer Hospital Sayre PA.
Ahmed N LoneDepartment of Medicine Erie County Medical Center Buffalo NY.
Muhammad Zia KhanDepartment of Medicine Erie County Medical Center Buffalo NY.
Muhammad Shahzeb KhanDepartment of Medicine John H Stroger Jr. Hospital of Cook County Chicago IL.
Ann M NavarDivision of Cardiology UT Southwestern Medical Center Dallas TX.
Martha GulatiDivision of Cardiology University of Arizona Phoenix AZ.
Heather JohnsonBoca Raton Regional Hospital/Baptist Health of South Florida Boca Raton FL.
Seth BaumExcel Medical Clinical Trials Boca Raton FL.
Erin D MichosThe Ciccarone Center for the Prevention of Cardiovascular Disease Johns Hopkins School of Medicine Baltimore MD.
Erie County Medical Center · USJohn H. Stroger, Jr. Hospital of Cook County · USBoca Raton Regional Hospital · USJohns Hopkins University · USParacelsus Medical University · ATSouthwestern Medical Center · USSUNY Upstate Medical University · USUniversity of Arizona · USWest Virginia University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Influenza infection causes considerable morbidity and mortality in patients with cardiovascular disease. We assessed the effects of the influenza vaccine on mortality and cardiovascular outcomes in patients with cardiovascular disease. Methods and Results We searched PubMed, Embase, and the Cochrane Library through January 2020 for randomized controlled trials and observational studies assessing the effects of influenza vaccine on mortality and cardiovascular outcomes in patients with cardiovascular disease. Estimates were reported as random effects risk ratios (RRs) with 95% CIs. Analyses were stratified by study design into randomized controlled trials and observational studies. A total of 16 studies (n=237 058), including 4 randomized controlled trials (n=1667) and 12 observational studies (n=235 391), were identified. Participants' mean age was 69.2±7.01 years, 36.6% were women, 65.1% had hypertension, 31.1% had diabetes mellitus, and 23.4% were smokers. At a median follow-up duration of 19.5 months, influenza vaccine was associated with a lower risk of all-cause mortality (RR, 0.75; 95% CI, 0.60-0.93 [

Indexed as

Cardiovascular DiseasesCause of DeathGlobal HealthHumansInfluenza A virusInfluenza, HumanInfluenza VaccinesPrognosisSecondary PreventionSurvival RateInfluenza Vaccinescardiovascular diseaseinfluenza vaccinemeta‐analysismortality

Identifiers

PMID33719496
PMCPMC8174205
OpenAlexW3136968442

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.