Evidence map›Paper›PMID 33719575›Full record

ArticleAmerican journal of physiology. Renal physiology2021

Indirect podocyte injury manifested in a partial podocytectomy mouse model.

Masahiro Okabe, Kazuyoshi Yamamoto, Yoichi Miyazaki, Masaru Motojima, Masato Ohtsuka, Ira Pastan, Takashi Yokoo, Taiji Matsusaka

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Injury-induced paracrine effects on the podocyte's transcriptome.American journal of physiology. Renal physiology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Podocytes are lost from glomeruli before completing apoptosis.American journal of physiology. Renal physiology · 2022
    Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Masahiro OkabeDivision of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.ORCID 0000-0002-0059-3542
Kazuyoshi YamamotoDivision of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
Yoichi MiyazakiDivision of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
Masaru MotojimaDepartment of Clinical Pharmacology, Tokai University School of Medicine, Isehara, Japan.
Masato OhtsukaDepartment of Basic Medicine, Tokai University School of Medicine, Isehara, Japan.
Ira PastanLaboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Takashi YokooDivision of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
Taiji MatsusakaDepartment of Basic Medicine, Tokai University School of Medicine, Isehara, Japan.ORCID 0000-0001-9466-4585
Jikei University School of Medicine · JPTokai University · JPNational Institutes of Health · US

Funding

Growth Regulation SectionZIABC010298 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI PASTAN, IRA · 2009 to 2023
$5.0M
6 · The paper itself

Abstract

In progressive glomerular diseases, segmental podocyte injury often expands, leading to global glomerulosclerosis by unclear mechanisms. To study the expansion of podocyte injury, we established a new mosaic mouse model in which a fraction of podocytes express human (h)CD25 and can be injured by the immunotoxin LMB2. hCD25

Indexed as

AnimalsEmbryonic Stem CellsGene Expression RegulationGreen Fluorescent ProteinsHumansImmunotoxinsInterleukin-2 Receptor alpha SubunitKidney DiseasesMiceMice, Inbred C57BLPodocytesenhanced green fluorescent proteinGreen Fluorescent ProteinsIL2RA protein, humanImmunotoxinsInterleukin-2 Receptor alpha Subunitfocal segmental glomerulosclerosisgene expressionpodocyteproteinuria

Identifiers

PMID33719575
PMCPMC8424557
OpenAlexW3138445632

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.