Evidence map›Paper›PMID 33724834›Full record

ArticleJournal of medicinal chemistry2021

Allosteric Site on SHIP2 Identified Through Fluorescent Ligand Screening and Crystallography: A Potential New Target for Intervention.

Hayley Whitfield, Andrew M Hemmings, Stephen J Mills, Kendall Baker, Gaye White, Stuart Rushworth, Andrew M Riley, Barry V L Potter, Charles A Brearley

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Small Molecule Insulin Sensitisers: New Leads and Targets for Next-Generation Insulin Sensitising Strategies.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Hayley WhitfieldSchool of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, U.K.
Andrew M HemmingsSchool of Chemistry, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, U.K.
Stephen J MillsMedicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U.K.
Kendall BakerSchool of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, U.K.
Gaye WhiteSchool of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, U.K.
Stuart RushworthDepartment of Molecular Haematology; Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, U.K.
Andrew M RileyMedicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U.K.ORCID 0000-0001-9003-3540
Barry V L PotterMedicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U.K.ORCID 0000-0003-3255-9135
Charles A BrearleySchool of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, U.K.ORCID 0000-0001-6179-9109
University of East Anglia · GBMansfield University · US

Funding

Biotechnology and Biological Sciences Research Council BB/N002024/1Wellcome Trust 101010
6 · The paper itself

Abstract

Src homology 2 domain-containing inositol phosphate phosphatase 2 (SHIP2) is one of the 10 human inositol phosphate 5-phosphatases. One of its physiological functions is dephosphorylation of phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4,5)P

Indexed as

Allosteric SiteAmino Acid SequenceAnimalsCatalytic DomainCell Line, TumorCrystallography, X-RayEnzyme InhibitorsFluoresceinsFluorescent DyesHumansInositol PhosphatesLigandsMiceMolecular Docking SimulationNIH 3T3 CellsPhosphatidylinositol-3,4,5-Trisphosphate 5-PhosphatasesEnzyme InhibitorsFluoresceinsFluorescent DyesInositol PhosphatesInppl1 protein, mouseLigandsPhosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases

Identifiers

PMID33724834
PMCPMC7610569
OpenAlexW3135133150

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.