ArticleCritical care (London, England)2021
Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method.
Article in Critical care (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 93 papers, 9 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Expert Panel Statement for the Respiratory Management of COVID-19 Related Acute Respiratory Failure (C-ARF) Using Modified Delphi Methodology
Safety and Efficacy of a Strategy Extending Duration of Prone Position in COVID-19-related ARDS Patients. a Retrospective Monocentric Observational Study
Expert Consensus On Definitions And Management Of Intra-Abdominal Hypertension And Abdominal Compartment Syndrome
Who cites it
93 citing papers in PubMed, 9 syntheses or guidelines pooled it, 191 citations in OpenAlex.
- Awake prone position in COVID-19-related acute respiratory failure: a meta-analysis of randomized controlled trials.BMC pulmonary medicine · 2023Pooled it
- Effects of awake prone position vs. usual care on acute hypoxemic respiratory failure in patients with COVID-19: A systematic review and meta-analysis of randomized controlled trials.Frontiers in medicine · 2023Pooled it
- Early spontaneous breathing for acute respiratory distress syndrome in individuals with COVID-19.The Cochrane database of systematic reviews · 2022Pooled it
- Awake prone positioning for non-intubated patients with COVID-19-related acute hypoxaemic respiratory failure: a systematic review and meta-analysis.The Lancet. Respiratory medicine · 2022Pooled it
- Tracheostomy timing and clinical outcomes in ventilated COVID-19 patients: a systematic review and meta-analysis.Critical care (London, England) · 2022Pooled it
- Air leak with COVID-19 - A meta-summary.Asian cardiovascular & thoracic annals · 2022Pooled it
- Pooled it
- Effect of prone versus supine position in COVID-19 patients: A systematic review and meta-analysis.Journal of clinical anesthesia · 2021Pooled it
- Respiratory rehabilitation in patients recovering from severe acute respiratory syndrome: A systematic review and meta-analysis.Heart & lung : the journal of critical carePooled it
- Effects of innovative modular prone positioning tools in patients with acute respiratory distress syndrome due to COVID-19 during awake prone position: a prospective randomized controlled trial.European journal of medical research · 2024Trial
- Convalescent Plasma for Covid-19-Induced ARDS in Mechanically Ventilated Patients.The New England journal of medicine · 2023Trial
- [Driving pressure-guided lung protective ventilation strategy reduces postoperative pulmonary complications in patients recovered from COVID-19].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Trial
- A Randomized Trial of Mesenchymal Stromal Cells for Moderate to Severe Acute Respiratory Distress Syndrome from COVID-19.American journal of respiratory and critical care medicine · 2023Trial
- Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial.The Lancet. Respiratory medicine · 2021Trial
- From the Oracle of Delphi to Intensive Care Unit Guidelines: Consensus Building Using the Delphi Method.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2026Article
- The Same Instrument, Differently Tuned? Surveys, Delphi Studies, and the Search for Structured Disagreement.Critical care explorations · 2026Article
- Timing and predictors of tracheostomy decannulation in COVID-19 and non-COVID-19 ARDS: A real-world study.Multidisciplinary respiratory medicine · 2026Article
- How to perform fluid de-escalation in critical care.Annals of intensive care · 2026Review
- Interprofessional education involving respiratory therapists: A narrative review of implementation models, educational outcomes, and research gaps.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2026Review
- Impact of proning with and without inhaled pulmonary vasodilators and neuromuscular blocking agents in COVID acute respiratory distress syndrome.World journal of critical care medicine · 2025Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
49 authors at 20 institutions in 23 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCoronavirus disease 2019 (COVID-19) pandemic has caused unprecedented pressure on healthcare system globally. Lack of high-quality evidence on the respiratory management of COVID-19-related acute respiratory failure (C-ARF) has resulted in wide variation in clinical practice.
methodsUsing a Delphi process, an international panel of 39 experts developed clinical practice statements on the respiratory management of C-ARF in areas where evidence is absent or limited. Agreement was defined as achieved when > 70% experts voted for a given option on the Likert scale statement or > 80% voted for a particular option in multiple-choice questions. Stability was assessed between the two concluding rounds for each statement, using the non-parametric Chi-square (χ
resultsAgreement was achieved for 27 (73%) management strategies which were then used to develop expert clinical practice statements. Experts agreed that COVID-19-related acute respiratory distress syndrome (ARDS) is clinically similar to other forms of ARDS. The Delphi process yielded strong suggestions for use of systemic corticosteroids for critical COVID-19; awake self-proning to improve oxygenation and high flow nasal oxygen to potentially reduce tracheal intubation; non-invasive ventilation for patients with mixed hypoxemic-hypercapnic respiratory failure; tracheal intubation for poor mentation, hemodynamic instability or severe hypoxemia; closed suction systems; lung protective ventilation; prone ventilation (for 16-24 h per day) to improve oxygenation; neuromuscular blocking agents for patient-ventilator dyssynchrony; avoiding delay in extubation for the risk of reintubation; and similar timing of tracheostomy as in non-COVID-19 patients. There was no agreement on positive end expiratory pressure titration or the choice of personal protective equipment.
conclusionUsing a Delphi method, an agreement among experts was reached for 27 statements from which 20 expert clinical practice statements were derived on the respiratory management of C-ARF, addressing important decisions for patient management in areas where evidence is either absent or limited.
trial registrationThe study was registered with Clinical trials.gov Identifier: NCT04534569.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.