SynthesisJournal of the American Heart Association2021
Surgical and Transcatheter Mitral Valve Replacement in Mitral Annular Calcification: A Systematic Review.
Synthesis in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Surgical and Transcatheter Mitral Valve Replacement in Mitral Annular Calcification: A Systematic Review.Journal of the American Heart Association · 2021Pooled it
- Design Variation, Implantation, and Outcome of Transcatheter Mitral Valve Prosthesis: A Comprehensive Review.Frontiers in cardiovascular medicine · 2021Pooled it
- Simultaneous TAVR and TMVR-in-MAC guided by 3D modelling and prosthesis modification: a case report.European heart journal. Case reports · 2026Article
- Prognostic Impact of Qualitative and Quantitative Mitral Valve Calcification in Transapical Transcatheter Mitral Valve Replacement: A Sub-Analysis of the TENDER Registry.Journal of clinical medicine · 2026Article
- Minimally Invasive Trans-atrial Mitral Valve Replacement Using a Balloon-expandable Transcatheter Valve in the Setting of Severe Mitral Annular Calcification.Cardiovascular drugs and therapy · 2026Article
- Surgical approach to mitral annular calcification-the Cleveland Clinic experience.Annals of cardiothoracic surgery · 2025Article
- Extensive posterior bar decalcification with novel calcific emulsification to enable endoscopic minimally invasive mitral valve repair.Annals of cardiothoracic surgery · 2025Article
- Mitral annular calcification: implications on clinical outcomes and interventions.Annals of cardiothoracic surgery · 2025Review
- Ultrasonic emulsification to facilitate mitral valve reconstruction in mitral annular calcification.Annals of cardiothoracic surgery · 2025Article
- Transcatheter mitral valve options for severe mitral annular calcification.Annals of cardiothoracic surgery · 2025Review
- The Emerging Role of Lithotripsy in Structural Heart Interventions.Current cardiology reports · 2025Review
- Feasibility, Efficacy, and Safety of the Mitral Annulo-TRIpsy in eXtreme Risk Patients.Structural heart : the journal of the Heart Team · 2025Article
- Mitral Annular Calcification: Natural History, Prognosis, and Clinical Outcomes.Journal of the Society for Cardiovascular Angiography & Interventions · 2025Article
- Mitral annular calcification in interventional cardiology: address all fears.AsiaIntervention · 2025Review
- Long-Term Outcomes After Mitral Valve Replacement in Sex- and Age-Matched Patients With vs Without Mitral Annular Calcification.CJC open · 2025Article
- Contemporary Outcomes and Trends for the Transseptal Mitral Valve-in-Valve Procedure Using Balloon Expandable Transcatheter Valves in the United States.Circulation · 2024Article
- Rheumatic and Degenerative Mitral Stenosis: From an Iconic Clinical Case to the Literature Review.Journal of cardiovascular development and disease · 2024Review
- AltaValve Atrial Fixation System for the Treatment of Severe Mitral Regurgitation and Mitral Annular Calcification.Structural heart : the journal of the Heart Team · 2024Article
- Mitral Annular Calcification-Related Valvular Disease: A Challenging Entity.Journal of clinical medicine · 2024Review
- Transaortic TAVR and Mitral Repair Under Deep Hypothermic Circulatory Arrest in a Porcelain Aorta Patient.JACC. Case reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitral annular calcification with mitral valve disease is a challenging problem that could necessitate surgical mitral valve replacement (SMVR). Transcatheter mitral valve replacement (TMVR) is emerging as a feasible alternative in high-risk patients with appropriate anatomy. PubMed, Embase, and Cochrane Central Register of Controlled Trials were searched from inception to December 25, 2019 for studies discussing SMVR or TMVR in patients with mitral annular calcification; 27 of 1539 articles were selected for final review. TMVR was used in 15 studies. Relevant data were available on 82 patients who underwent hybrid transatrial TMVR, and 354 patients who underwent transapical or transseptal TMVR. Outcomes on SMVR were generally reported as small case series (447 patients from 11 studies); however, 1 large study recently reported outcomes in 9551 patients. Patients who underwent TMVR had a shorter median follow-up of 9 to 12 months (range, in-hospital‒19 months) compared with patients with SMVR (54 months; range, in-hospital‒120 months). Overall, those undergoing TMVR were older and had higher Society of Thoracic Surgeons risk scores. SMVR showed a wide range of early (0%-27%; median 6.3%) and long-term mortality (0%-65%; median at 1 year, 15.8%; 5 years, 38.8%, 10 years, 62.4%). The median in-hospital, 30-day, and 1-year mortality rates were 16.7%, 22.7%, and 43%, respectively, for transseptal/transapical TMVR, and 9.5%, 20.0%, and 40%, respectively, for transatrial TMVR. Mitral annular calcification is a complex disease and TMVR, with a versatile option of transatrial approach in patients with challenging anatomy, offers a promising alternative to SMVR in high-risk patients. However, further studies are needed to improve technology, patient selection, operative expertise, and long-term outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.