Evidence map›Paper›PMID 33729108›Full record

ArticleParasitology2021

Leandro de Mattos Pereira, Milene Pereira Guimarães de Jezuz, Amaranta Ramos Rangel, Bruna Dalcin Baldasso, Amanda Bungi Zaluski, Carlos Graeff-Teixeira, Alessandra Loureiro Morassutti

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasitology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Leandro de Mattos PereiraLaboratório de Biologia Parasitária, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Escola de Ciências, Porto Alegre, RS, Brazil.ORCID 0000-0002-2311-7469
Milene Pereira Guimarães de JezuzLaboratório de Biologia Parasitária, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Escola de Ciências, Porto Alegre, RS, Brazil.
Amaranta Ramos RangelLaboratório de Biologia Parasitária, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Escola de Ciências, Porto Alegre, RS, Brazil.
Bruna Dalcin BaldassoLaboratório de Biologia Parasitária, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Escola de Ciências, Porto Alegre, RS, Brazil.
Amanda Bungi ZaluskiLaboratório de Biologia e Desenvolvimento do Sistema Nervoso, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Escola de Ciências, Porto Alegre, RS, Brazil.
Carlos Graeff-TeixeiraLaboratório de Biologia Parasitária, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Escola de Ciências, Porto Alegre, RS, Brazil.ORCID 0000-0003-2725-0061
Alessandra Loureiro MorassuttiEscola de Medicina IMED, Passo Fundo, RS99070-220, Brazil.ORCID 0000-0002-8142-1055
Pontifícia Universidade Católica do Rio Grande do Sul · BRUniversidade de Passo Fundo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Angiostrongylus cantonensis is the main aetiological agent of eosinophilic meningoencephalitis in humans. Several outbreaks have been documented around the world, cementing its status as an emerging global public health concern. As a result, new strategies for the diagnosis, prophylaxis and treatment of cerebral angiostrongyliasis are urgently needed. In this study, we report on the de novo assembly of the A. cantonensis transcriptome, its full functional annotation and a reconstruction of complete metabolic pathways. All results are available at AngiostrongylusDB (http://angiostrongylus.lad.pucrs.br/admin/welcome). The aim of this study was to identify the active genes and metabolic pathways involved in the mechanisms of infection and survival inside Rattus norvegicus. Among 389 metabolic mapped pathways, the blood coagulation/antithrombin pathways of heparan sulphate/heparin are highlighted. Moreover, we identified genes codified to GP63 (leishmanolysin), CALR (calreticulin), ACE (peptidyl-dipeptidase A), myoglobin and vWD (von Willebrand factor type D domain protein) involved in the infection invasion and survival of the parasite. The large dataset of functional annotations provided and the full-length transcripts identified in this research may facilitate future functional genomics studies and provides a basis for the development of new techniques for the diagnosis, prevention and treatment of cerebral angiostrongyliasis.

Indexed as

TranscriptomeAngiostrongylus cantonensisAnimalsAntithrombinsBlood Coagulation FactorsFemaleRatsStrongylida InfectionsAntithrombinsBlood Coagulation FactorsA. cantonensis transcriptomeAngiostrongylus cantonensisanticoagulant/antithrombotic pathwayscerebral angiostrongyliasiseosinophilic meningitisfunctional annotationmolecular diagnostics

Identifiers

PMID33729108
PMCPMC11010222
OpenAlexW3139175317

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.