Evidence map›Paper›PMID 33737507›Full record

ReviewSignal transduction and targeted therapy2021

Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties.

Kieran Joyce, Georgina Targa Fabra, Yagmur Bozkurt, Abhay Pandit

Erratum issuedOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Signal transduction and targeted therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 104 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 1 pooled it
15.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 1 synthesis or guideline pooled it, 284 citations in OpenAlex.

  1. Pooled it
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  11. Acellular Adipose Tissue promotes anti-fibrotic remodeling in Phase II Study.medRxiv : the preprint server for health sciences · 2026
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44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kieran JoyceSchool of Medicine, National University of Ireland, Galway, Ireland.
Georgina Targa FabraCÚRAM, SFI Research Centre for Medical Devices, National University of Ireland, Galway, Ireland.
Yagmur BozkurtCÚRAM, SFI Research Centre for Medical Devices, National University of Ireland, Galway, Ireland.
Abhay PanditCÚRAM, SFI Research Centre for Medical Devices, National University of Ireland, Galway, Ireland. abhay.pandit@nuigalway.ie.ORCID http://orcid.org/0000-0002-6292-4933
Ollscoil na Gaillimhe – University of Galway · IEScience Foundation Ireland · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biomaterials have had an increasingly important role in recent decades, in biomedical device design and the development of tissue engineering solutions for cell delivery, drug delivery, device integration, tissue replacement, and more. There is an increasing trend in tissue engineering to use natural substrates, such as macromolecules native to plants and animals to improve the biocompatibility and biodegradability of delivered materials. At the same time, these materials have favourable mechanical properties and often considered to be biologically inert. More importantly, these macromolecules possess innate functions and properties due to their unique chemical composition and structure, which increase their bioactivity and therapeutic potential in a wide range of applications. While much focus has been on integrating these materials into these devices via a spectrum of cross-linking mechanisms, little attention is drawn to residual bioactivity that is often hampered during isolation, purification, and production processes. Herein, we discuss methods of initial material characterisation to determine innate bioactivity, means of material processing including cross-linking, decellularisation, and purification techniques and finally, a biological assessment of retained bioactivity of a final product. This review aims to address considerations for biomaterials design from natural polymers, through the optimisation and preservation of bioactive components that maximise the inherent bioactive potency of the substrate to promote tissue regeneration.

Indexed as

Tissue EngineeringAnimalsBiocompatible MaterialsBiological ProductsBiopolymersHumansPhytochemicalsBiocompatible MaterialsBiological ProductsBiopolymersPhytochemicals

Identifiers

PMID33737507
PMCPMC7973744
OpenAlexW3138816562

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.